S
Senthilkumar S. Karuppagounder
Researcher at Johns Hopkins University School of Medicine
Publications - 57
Citations - 5000
Senthilkumar S. Karuppagounder is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Parkinson's disease. The author has an hindex of 27, co-authored 47 publications receiving 3479 citations. Previous affiliations of Senthilkumar S. Karuppagounder include Auburn University & Johns Hopkins University.
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Journal ArticleDOI
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Seung Pil Yun,Tae In Kam,Nikhil Panicker,SangMin Kim,Yumin Oh,Jong-Sung Park,Seung-Hwan Kwon,Yong Joo Park,Senthilkumar S. Karuppagounder,Hyejin Park,Sangjune Kim,Nayeon Oh,Nayoung Alice Kim,Saebom Lee,Saurav Brahmachari,Xiaobo Mao,Jun Hee Lee,Manoj Kumar,Daniel An,Sung Ung Kang,Yunjong Lee,Kang Choon Lee,Dong Hee Na,Dong-Hoon Kim,Sang Hun Lee,Viktor V. Roschke,Shane A. Liddelow,Zoltan Mari,Ben A. Barres,Valina L. Dawson,Seulki Lee,Ted M. Dawson,Han Seok Ko +32 more
TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.
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Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Xiaobo Mao,Michael Tianhao Ou,Senthilkumar S. Karuppagounder,Tae In Kam,Xiling Yin,Yulan Xiong,Preston Ge,George Essien Umanah,Saurav Brahmachari,Joo Ho Shin,Joo Ho Shin,Ho Chul Kang,Ho Chul Kang,Jianmin Zhang,Jinchong Xu,Rong Chen,Hyejin Park,Shaida A. Andrabi,Sung Ung Kang,Rafaella Araújo Gonçalves,Yu Liang,Shu Zhang,Chen Qi,Chen Qi,Sharon Lam,James A. Keiler,Joel Tyson,Joel Tyson,Dong-Hoon Kim,Nikhil Panicker,Seung Pil Yun,Creg J. Workman,Dario A. A. Vignali,Valina L. Dawson,Han Seok Ko,Ted M. Dawson +35 more
TL;DR: It is discovered that pathologic α- Synuclein transmission and toxicity is initiated by binding to LAG3 and that neuron-to-neuron transmission of pathological α-synuclein involves the endocytosis of exogenous α- synuclein PFF by the engagement of L AG3 on neurons.
Journal ArticleDOI
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Tae In Kam,Xiaobo Mao,Hyejin Park,Shih Ching Chou,Senthilkumar S. Karuppagounder,George Essien Umanah,Seung Pil Yun,Saurav Brahmachari,Nikhil Panicker,Rong Chen,Shaida A. Andrabi,Chen Qi,Chen Qi,Guy G. Poirier,Olga Pletnikova,Juan C. Troncoso,Lynn M. Bekris,James B. Leverenz,Alexander Pantelyat,Han Seok Ko,Liana S. Rosenthal,Ted M. Dawson,Valina L. Dawson +22 more
TL;DR: Parkinson’s disease (PD) is the second most common neurodegenerative disorder and the cellular cell death pathways that contribute to and drive α-synuclein PFF–mediated neuronal cell death are investigated, which indicates that PARP activation contributes to the pathogenesis of PD through parthanatos and conversion of α- syn to a more toxic strain.
Journal ArticleDOI
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
Han Seok Ko,Yunjong Lee,Joo Ho Shin,Senthilkumar S. Karuppagounder,Bharathi S. Gadad,Anthony J. Koleske,Olga Pletnikova,Juan C. Troncoso,Valina L. Dawson,Ted M. Dawson +9 more
TL;DR: In this paper, Parkin's ubiquitin E3 ligase activity and protective function was inhibited by the non-receptor tyrosine kinase c-Abl.