J
Jun Hee Lee
Researcher at Soonchunhyang University
Publications - 82
Citations - 3576
Jun Hee Lee is an academic researcher from Soonchunhyang University. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 25, co-authored 77 publications receiving 2360 citations. Previous affiliations of Jun Hee Lee include Pusan National University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Seung Pil Yun,Tae In Kam,Nikhil Panicker,SangMin Kim,Yumin Oh,Jong-Sung Park,Seung-Hwan Kwon,Yong Joo Park,Senthilkumar S. Karuppagounder,Hyejin Park,Sangjune Kim,Nayeon Oh,Nayoung Alice Kim,Saebom Lee,Saurav Brahmachari,Xiaobo Mao,Jun Hee Lee,Manoj Kumar,Daniel An,Sung Ung Kang,Yunjong Lee,Kang Choon Lee,Dong Hee Na,Dong-Hoon Kim,Sang Hun Lee,Viktor V. Roschke,Shane A. Liddelow,Zoltan Mari,Ben A. Barres,Valina L. Dawson,Seulki Lee,Ted M. Dawson,Han Seok Ko +32 more
TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.
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Tissue Engineered Bio-Blood-Vessels Constructed Using a Tissue-Specific Bioink and 3D Coaxial Cell Printing Technique: A Novel Therapy for Ischemic Disease
Ge Gao,Jun Hee Lee,Jinah Jang,Dong Han Lee,Jeong-Sik Kong,Byoung Soo Kim,Yeong-Jin Choi,Woong Bi Jang,Young Joon Hong,Sang-Mo Kwon,Dong-Woo Cho +10 more
TL;DR: The outcomes suggest that the 3D‐printed ECM‐mediated cell/drug implantation can be a new therapeutic approach for the treatment of various ischemic diseases.
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Hypoxic Preconditioning Promotes the Bioactivities of Mesenchymal Stem Cells via the HIF-1α-GRP78-Akt Axis.
TL;DR: It is indicated that hypoxic preconditioning promotes survival, proliferation, and angiogenic cytokine secretion of MSCs via the HIF-1α-GRP78-Akt signal pathway, suggesting that hypoxia-preconditioned MSC’s might provide a therapeutic strategy for MSC-based therapies and that GRP78 represents a potential target for the development of functional M SCs.
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Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells.
TL;DR: It is suggested that MSC spheroids promote MSC bioactivities via secretion of angiogenic cytokines, preservation of ECM components, and regulation of apoptotic signals, and may serve as a simple and effective strategy for regenerative medicine.