Partha Krishnamurthy

TL;DR: The studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions and suggest that cells can, upon hypoxic demand, use BCRP to reduce heme or porphyrin accumulation, which can be detrimental to cells.

TL;DR: In vivo studies of Abcg2 function in host and cellular defense and immunohistochemical analyses have revealed how ABCG2 influences the absorption, distribution, and excretion of drugs and cytotoxins.

TL;DR: It is demonstrated that ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake and is challenging previous assumptions about the intracellular movement of porphyrs and the factors controlling haem biosynthesis.

TL;DR: The roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 are discussed and how these transporters contribute to intracellular heme and porphyrin homeostasis are discussed.

TL;DR: It is found that ethanol feeding plus an acute binge decreased hepatic expression of TFEB, which is required for lysosomal biogenesis and autophagy, and strategies to block mTOR activity or increase levels of T FEB might be developed to protect the liver from ethanol-induced damage.