Journal ArticleDOI
The role of transporters in cellular heme and porphyrin homeostasis
TLDR
The roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 are discussed and how these transporters contribute to intracellular heme and porphyrin homeostasis are discussed.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2007-06-01. It has received 224 citations till now. The article focuses on the topics: Heme carrier protein 1 & Heme.read more
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Phytate: impact on environment and human nutrition. A challenge for molecular breeding
TL;DR: Biochemical data for purified and characterized phytases isolated from more than 23 plant species are presented, the dephosphorylation pathways of phytic acid by different classes ofphytases are compared, and the application of phytase in food and feed is discussed.
Journal ArticleDOI
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Paolo Bernardi,Andrea Rasola,Andrea Rasola,Andrea Rasola,Michael Forte,Giovanna Lippe,Giovanna Lippe,Giovanna Lippe +7 more
TL;DR: Structural and functional features of F-ATP synthases are discussed that may provide clues to its transition from an energy-conserving into anEnergy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
Journal ArticleDOI
The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection
Paolo Bernardi,Fabio Di Lisa +1 more
TL;DR: An update on the current debate on how the mitochondrial permeability transition is achieved is provided, and on the PTP as a target for therapeutic intervention is provided.
Journal ArticleDOI
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance.
TL;DR: Evidence is mounting that many cancers display subpopulations of stem cells that are responsible for tumor self-renewal, and stem cells frequently manifest the "side population" phenotype characterized by expression of BCRP and other ABC transporters, which may contribute to the inherent resistance of these neoplasms and their failure to be cured.
Journal ArticleDOI
An update on iron physiology
TL;DR: In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACC + ID).
References
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Journal ArticleDOI
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Sheng Zhou,John D. Schuetz,Kevin D. Bunting,Anne-Marie Colapietro,Janardhan Sampath,John J. Morris,Irina Lagutina,Gerard Grosveld,Mitsujiro Osawa,Hiromitsu Nakauchi,Brian P. Sorrentino +10 more
TL;DR: Results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.
Journal ArticleDOI
A multidrug resistance transporter from human MCF-7 breast cancer cells
L. Austin Doyle,Weidong Yang,Lynne V. Abruzzo,Tammy Krogmann,Y. Gao,Arun K. Rishi,Douglas D. Ross,Douglas D. Ross +7 more
TL;DR: In this article, the authors identify a 2.4-kb mRNA that encodes a 663-aa member of the ATP-binding cassette superfamily of transporters that they termed breast cancer resistance protein (BCRP).
Journal Article
The major facilitator superfamily.
Milton H. Saier,Beatty Jt,André Goffeau,Kevin T. Harley,Wilbert H.M. Heijne,Huang Sc,Donald L. Jack,Jähn Ps,Lew K,Jun Liu,Stephanie S. Pao,Ian T. Paulsen,Tsai-Tien Tseng,Virk Ps +13 more
TL;DR: Evidence is presented substantiating the proposal that an internal tandem gene duplication event gave rise to a primordial MFS protein before divergence of the family members.
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Major Facilitator Superfamily
TL;DR: The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth as discussed by the authors, and all homologous MFS protein sequences in the public databases as of January 1997 were identified on the basis of sequence similarity.
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.