P
Partha Krishnamurthy
Researcher at University of Kansas
Publications - 37
Citations - 3115
Partha Krishnamurthy is an academic researcher from University of Kansas. The author has contributed to research in topics: ATP-binding cassette transporter & Heme. The author has an hindex of 23, co-authored 37 publications receiving 2680 citations. Previous affiliations of Partha Krishnamurthy include St. Jude Children's Research Hospital.
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Journal ArticleDOI
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
Partha Krishnamurthy,Douglas D. Ross,Douglas D. Ross,Takeo Nakanishi,Kim Bailey-Dell,Sheng Zhou,Kelly E. Mercer,Balázs Sarkadi,Brian P. Sorrentino,John D. Schuetz +9 more
TL;DR: The studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions and suggest that cells can, upon hypoxic demand, use BCRP to reduce heme or porphyrin accumulation, which can be detrimental to cells.
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Role of abcg2/bcrp in biology and medicine
TL;DR: In vivo studies of Abcg2 function in host and cellular defense and immunohistochemical analyses have revealed how ABCG2 influences the absorption, distribution, and excretion of drugs and cytotoxins.
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Identification of a mammalian mitochondrial porphyrin transporter
Partha Krishnamurthy,Guoqing Du,Yu Fukuda,Daxi Sun,Janardhan Sampath,Kelly E. Mercer,Junfeng Wang,Beatriz Sosa-Pineda,K. Gopal Murti,John D. Schuetz +9 more
TL;DR: It is demonstrated that ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake and is challenging previous assumptions about the intracellular movement of porphyrs and the factors controlling haem biosynthesis.
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The role of transporters in cellular heme and porphyrin homeostasis
TL;DR: The roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 are discussed and how these transporters contribute to intracellular heme and porphyrin homeostasis are discussed.
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Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Xiaojuan Chao,Shaogui Wang,Katrina Zhao,Yuan Li,Jessica A. Williams,Tiangang Li,Hemantkumar Chavan,Partha Krishnamurthy,Xi C. He,Linheng Li,Linheng Li,Andrea Ballabio,Hong-Min Ni,Wen-Xing Ding +13 more
TL;DR: It is found that ethanol feeding plus an acute binge decreased hepatic expression of TFEB, which is required for lysosomal biogenesis and autophagy, and strategies to block mTOR activity or increase levels of T FEB might be developed to protect the liver from ethanol-induced damage.