P
Pascal Pujol
Researcher at University of Montpellier
Publications - 22
Citations - 305
Pascal Pujol is an academic researcher from University of Montpellier. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 9, co-authored 22 publications receiving 187 citations. Previous affiliations of Pascal Pujol include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Identifying key questions in the ecology and evolution of cancer.
Antoine M. Dujon,Antoine M. Dujon,Athena Aktipis,Catherine Alix-Panabières,Sarah R. Amend,Amy M. Boddy,Joel S. Brown,Jean Pascal Capp,James DeGregori,Paul W. Ewald,Robert A. Gatenby,Marco Gerlinger,Mathieu Giraudeau,Mathieu Giraudeau,Rodrigo Hamede,Elsa Hansen,Irina Kareva,Carlo C. Maley,Andriy Marusyk,Nicholas McGranahan,Nicholas McGranahan,Michael J. Metzger,Aurora M. Nedelcu,Robert Noble,Robert Noble,Leonard Nunney,Kenneth J. Pienta,Kornelia Polyak,Pascal Pujol,Andrew F. Read,Benjamin Roche,Benjamin Roche,Susanne Sebens,Eric Solary,Eric Solary,Kateřina Staňková,Kateřina Staňková,Holly A. Swain Ewald,Frédéric Thomas,Beata Ujvari +39 more
TL;DR: The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years as mentioned in this paper.
Journal ArticleDOI
Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests
Pascal Pujol,Pascal Pujol,D. Stoppa Lyonnet,Thierry Frebourg,J. Blin,M. C. Picot,Christine Lasset,Catherine Dugast,Pascaline Berthet,B. Bressac de Paillerets,Hagay Sobol,Sophie Grandjouan,Florent Soubrier,Bruno Buecher,Rosine Guimbaud,Rosette Lidereau,Philippe Jonveaux,Claude Houdayer,S. Giraud,Sylviane Olschwang,E. Nogue,Virginie Galibert,C. Bara,Frédérique Nowak,D. Khayat,Catherine Noguès +25 more
TL;DR: This nationwide study shows a lack of referral and genetic testing in Lynch as compared to HBOC syndromes and enhanced information about benefit of genetic testing should be given to clinicians and patients for Lynch syndrome and relatives of a proband carrying an identified predisposing mutation.
Journal ArticleDOI
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Alexandre Prieur,Monica Cappellini,Guillaume Habif,Marie-Paule Lefranc,Thibault Mazard,Eric Morency,Jean-Marc Pascussi,Maud Flacelière,Nathalie Cahuzac,Berengere Vire,Benjamin Dubuc,Amandine Durochat,Pierre Liaud,Jérémy Ollier,Caroline Pfeiffer,Sophie Poupeau,Veronique Saywell,Chris Planque,Eric Assenat,Frédéric Bibeau,Jean-François Bourgaux,Pascal Pujol,Alain Sézeur,Marc Ychou,Dominique Joubert +24 more
TL;DR: Data show that humanized anti-progastrin antibodies might represent a potential new treatment for K-RAS–mutated colorectal patients, for which there is a crucial unmet medical need.
Journal ArticleDOI
Is Adaptive Therapy Natural
Frédéric Thomas,Emmanuel Donnadieu,Emmanuel Donnadieu,Emmanuel Donnadieu,Guillaume M. Charrière,Camille Jacqueline,Aurélie Tasiemski,Pascal Pujol,François Renaud,Benjamin Roche,Benjamin Roche,Benjamin Roche,Rodrigo Hamede,Rodrigo Hamede,Joel S. Brown,Robert A. Gatenby,Beata Ujvari,Beata Ujvari +17 more
TL;DR: The potential risks of immunotherapies that force the immune system to ramp up the short-term kill rates of malignant cancer cells in a manner that undermines the body’s NAT and accelerates the evolution of immune resistance are discussed.
Journal ArticleDOI
Is There One Key Step in the Metastatic Cascade
Antoine M. Dujon,Antoine M. Dujon,Jean-Pascal Capp,Joel S. Brown,Pascal Pujol,Robert A. Gatenby,Beata Ujvari,Beata Ujvari,Catherine Alix-Panabières,Frédéric Thomas +9 more
TL;DR: In this article, a modified Drake equation was used to estimate the probability of the emergence of intelligent civilizations in the Milky Way, and the contribution of each component of the metastatic cascade was examined under the linear progression hypothesis.