Identifying key questions in the ecology and evolution of cancer.
Antoine M. Dujon,Antoine M. Dujon,Athena Aktipis,Catherine Alix-Panabières,Sarah R. Amend,Amy M. Boddy,Joel S. Brown,Jean Pascal Capp,James DeGregori,Paul W. Ewald,Robert A. Gatenby,Marco Gerlinger,Mathieu Giraudeau,Mathieu Giraudeau,Rodrigo Hamede,Elsa Hansen,Irina Kareva,Carlo C. Maley,Andriy Marusyk,Nicholas McGranahan,Nicholas McGranahan,Michael J. Metzger,Aurora M. Nedelcu,Robert Noble,Robert Noble,Leonard Nunney,Kenneth J. Pienta,Kornelia Polyak,Pascal Pujol,Andrew F. Read,Benjamin Roche,Benjamin Roche,Susanne Sebens,Eric Solary,Eric Solary,Kateřina Staňková,Kateřina Staňková,Holly A. Swain Ewald,Frédéric Thomas,Beata Ujvari +39 more
TLDR
The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years as mentioned in this paper.Abstract:
The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco-evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed. Here, we aim to assess current advancements in the field and to suggest future directions for research. First, we summarize cancer research areas that, so far, have assimilated ecological and evolutionary principles into their approaches and illustrate their key importance. Then, we assembled 33 experts and identified 84 key questions, organized around nine major themes, to pave the foundations for research to come. We highlight the urgent need for broadening the portfolio of research directions to stimulate novel approaches at the interface of oncology and ecological and evolutionary sciences. We conclude that progressive and efficient cross-disciplinary collaborations that draw on the expertise of the fields of ecology, evolution and cancer are essential in order to efficiently address current and future questions about cancer.read more
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The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer
Benjamin Wölfl,Hedy te Rietmole,Monica Salvioli,Monica Salvioli,Artem Kaznatcheev,Artem Kaznatcheev,Frank Thuijsman,Joel S. Brown,Boudewijn M.T. Burgering,Kateřina Staňková,Kateřina Staňková +10 more
TL;DR: It is suggested that cancer progression is an evolutionary competition between different cell types and therefore needs to be viewed as an evolutionary game and has medically useful implications that can inform and create a lockstep between empirical findings and mathematical modeling.
Journal ArticleDOI
Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem
TL;DR: Wang et al. as discussed by the authors proposed that the nature of head neck cancer is not a genetic disease but an ecological disease: a multidimensional spatiotemporal "unity of ecology and evolution" pathological ecosystem.
Posted ContentDOI
Measuring competitive exclusion in non-small cell lung cancer
Nathan Farrokhian,Jeff Maltas,Mina N. Dinh,Arda Durmaz,Patrick Ellsworth,Masahiro Hitomi,Erin McClure,Andriy Marusyk,Artem Kaznatcheev,Artem Kaznatcheev,Jacob G. Scott,Jacob G. Scott +11 more
TL;DR: In this article, the frequency-dependent interactions between a gefitinib resistant non-small cell lung cancer (NSCLC) population and its sensitive ancestor via the evolutionary game assay are measured.
Journal ArticleDOI
Polyploidy as a Fundamental Phenomenon in Evolution, Development, Adaptation and Diseases
TL;DR: The role of cell polyploidy in biological processes and epigenetic mechanisms has been investigated in this paper , where the authors found that the evolutionarily conserved features of cell and organism polyploids include activation of transcription, response to stress, DNA damage and hypoxia, and induction of programs of morphogenesis, unicellularity, and longevity.
Journal ArticleDOI
Is There One Key Step in the Metastatic Cascade
Antoine M. Dujon,Antoine M. Dujon,Jean-Pascal Capp,Joel S. Brown,Pascal Pujol,Robert A. Gatenby,Beata Ujvari,Beata Ujvari,Catherine Alix-Panabières,Frédéric Thomas +9 more
TL;DR: In this article, a modified Drake equation was used to estimate the probability of the emergence of intelligent civilizations in the Milky Way, and the contribution of each component of the metastatic cascade was examined under the linear progression hypothesis.
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