P
Patrick Descombes
Researcher at University of Geneva
Publications - 55
Citations - 10076
Patrick Descombes is an academic researcher from University of Geneva. The author has contributed to research in topics: Gene expression profiling & Genome-wide association study. The author has an hindex of 39, co-authored 50 publications receiving 9626 citations. Previous affiliations of Patrick Descombes include Carnegie Mellon University & Geneva College.
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Journal ArticleDOI
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Jacques Fellay,Kevin V. Shianna,Dongliang Ge,Sara Colombo,Bruno Ledergerber,Michael E. Weale,Kunlin Zhang,Curtis Gumbs,Antonella Castagna,Andrea Cossarizza,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,P Francioli,Simon Mallal,Javier Martinez-Picado,José M. Miró,Niels Obel,Jason Smith,Josiane Wyniger,Patrick Descombes,Stylianos E. Antonarakis,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Amalio Telenti,David Goldstein +26 more
TL;DR: Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
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Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study
Andri Rauch,Zoltán Kutalik,Zoltán Kutalik,Patrick Descombes,Tao Cai,Julia di Iulio,Tobias Mueller,Murielle Bochud,Manuel Battegay,Enos Bernasconi,Jan Borovicka,Sara Colombo,Andreas Cerny,Jean-François Dufour,Hansjakob Furrer,Huldrych F. Günthard,Markus H. Heim,Bernard Hirschel,Raffaele Malinverni,Darius Moradpour,Beat Müllhaupt,Andrea Witteck,Jacques S. Beckmann,Jacques S. Beckmann,Thomas Berg,Sven Bergmann,Sven Bergmann,Francesco Negro,Amalio Telenti,Pierre-Yves Bochud +29 more
TL;DR: The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis ofHCV infection.
Journal ArticleDOI
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA.
TL;DR: The LAP/LIP ratio increases about 5-fold during terminal rat liver differentiation and is thus likely to modulate the activity of LAP in the intact animal, possibly owing to its higher affinity for its DNA cognate sequences.
Journal ArticleDOI
LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.
Patrick Descombes,Mario Chojkier,Serge Patrick Lichtsteiner,Eileen Elisabeth Falvey,Ulrich Schibler +4 more
TL;DR: Although correctly initiated transcripts from the LAP gene accumulate in the six examined tissues--liver, lung, spleen, kidney, brain, and testis--LAP protein is highly enriched in liver nuclei, the preferential accumulation of LAP protein in liver appears to be regulated post-transcriptionally.
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The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
TL;DR: Compared the liver and kidney transcriptomes of these animals to those of wild-type or heterozygous mutant mice revealed that PAR bZip proteins control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).