K
Kunlin Zhang
Researcher at Chinese Academy of Sciences
Publications - 88
Citations - 3825
Kunlin Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Computer science & Genome-wide association study. The author has an hindex of 18, co-authored 42 publications receiving 3462 citations. Previous affiliations of Kunlin Zhang include Peking University & University of Lausanne.
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Journal ArticleDOI
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Jacques Fellay,Kevin V. Shianna,Dongliang Ge,Sara Colombo,Bruno Ledergerber,Michael E. Weale,Kunlin Zhang,Curtis Gumbs,Antonella Castagna,Andrea Cossarizza,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,P Francioli,Simon Mallal,Javier Martinez-Picado,José M. Miró,Niels Obel,Jason Smith,Josiane Wyniger,Patrick Descombes,Stylianos E. Antonarakis,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Amalio Telenti,David Goldstein +26 more
TL;DR: Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
Journal Article
Common Genetic Variation and the Control of HIV-1 in Humans
Jacques Fellay,Dongliang Ge,Kevin V. Shianna,Sara Colombo,Bruno Ledergerber,Elizabeth T. Cirulli,Thomas J. Urban,Kunlin Zhang,Curtis Gumbs,Jason Smith,Antonella Castagna,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,Huldrych F. Günthard,Simon Mallal,Cristina Mussini,Judith Dalmau,Javier Martinez-Picado,José M. Miró,Niels Obel,Steven M. Wolinsky,Jeremy J. Martinson,Roger Detels,Joseph B. Margolick,Lisa P. Jacobson,Patrick Descombes,Stylianos E. Antonarakis,Jacques S. Beckmann,Stephen J. O'Brien,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Mary Carrington,Sheng Feng,Amalio Telenti,David Goldstein,Aids Vaccine Immunology +37 more
TL;DR: The authors performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects and found common genetic variants explaining down to 1.3% of the variability in viral load at set point.
Journal ArticleDOI
Common genetic variation and the control of HIV-1 in humans.
Jacques Fellay,Dongliang Ge,Kevin V. Shianna,Sara Colombo,Bruno Ledergerber,Elizabeth T. Cirulli,Thomas J. Urban,Kunlin Zhang,Curtis Gumbs,Jason Smith,Antonella Castagna,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa J. Easterbrook,Huldrych F. Günthard,Simon Mallal,Cristina Mussini,Judith Dalmau,Javier Martinez-Picado,José M. Miró,Niels Obel,Steven M. Wolinsky,Jeremy J. Martinson,Roger Detels,Joseph B. Margolick,Lisa P. Jacobson,Patrick Descombes,Stylianos E. Antonarakis,Jacques S. Beckmann,Stephen J. O'Brien,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Mary Carrington,Mary Carrington,Sheng Feng,Amalio Telenti,David Goldstein +37 more
TL;DR: This study provides overwhelming confirmation of three associations previously reported in a genome-wide study and shows further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC).
Journal ArticleDOI
The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies.
TL;DR: The results indicated a reduced caudate response during both monetary anticipation and outcome stages as well as increased activation in the middle frontal gyrus and dorsal anterior cingulate during reward anticipation in MDD.
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i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study
TL;DR: To provide researchers an open platform to analyze GWAS data, the i-GSEA4GWAS (improved GSEA for GWAS) web server is developed and aims to provide new insights in complex disease studies.