P
Patrick J. Wijchers
Researcher at Utrecht University
Publications - 18
Citations - 2289
Patrick J. Wijchers is an academic researcher from Utrecht University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 15, co-authored 18 publications receiving 2038 citations. Previous affiliations of Patrick J. Wijchers include Imperial College London & University Medical Center Utrecht.
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Journal ArticleDOI
CTCF Binding Polarity Determines Chromatin Looping
Elzo de Wit,E.S. Vos,Sjoerd J B Holwerda,Christian Valdes-Quezada,Marjon J.A.M. Verstegen,Hans Teunissen,Erik Splinter,Patrick J. Wijchers,Peter H.L. Krijger,Wouter de Laat +9 more
TL;DR: It is concluded that CTCF binding polarity plays a functional role in the formation of higher-order chromatin structure.
Journal ArticleDOI
eRNAs are required for p53-dependent enhancer activity and gene transcription
Carlos A. Melo,Carlos A. Melo,Jarno Drost,Patrick J. Wijchers,Harmen J.G. van de Werken,Elzo de Wit,Joachim A.F. Oude Vrielink,Ran Elkon,Sonia A. Melo,Nicolas Léveillé,Raghu Kalluri,Raghu Kalluri,Wouter de Laat,Reuven Agami +13 more
TL;DR: This work ascribes transcription enhancement activity to p53 with the capacity to regulate multiple genes from a single genomic binding site and produces enhancer RNAs that are required for efficient transcriptional enhancement of interacting target genes and induction of a p53-dependent cell-cycle arrest.
Journal ArticleDOI
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.
Frank M. J. Jacobs,Lars P. van der Heide,Patrick J. Wijchers,J. Peter H. Burbach,Marco F.M. Hoekman,Marten P. Smidt +5 more
TL;DR: The cloning and characterization of a novel forkhead domain gene from mouse that appeared to be highly related to the FoxO group of transcription factors and was therefore designated FoxO6 is described, giving a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion ofFoxO-proteins.
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Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA
Nicolas Léveillé,Carlos A. Melo,Carlos A. Melo,Koos Rooijers,Angel Diaz-Lagares,Sonia Melo,Gozde Korkmaz,Rui Lopes,Farhad Akbari Moqadam,Ana Maia,Patrick J. Wijchers,Geert Geeven,Monique L. den Boer,Raghu Kalluri,Wouter de Laat,Manel Esteller,Manel Esteller,Reuven Agami,Reuven Agami +18 more
TL;DR: Among p53-induced lncRNAs, LED is identified and it is demonstrated that its suppression attenuates p53 function, and its dysregulation in cancer is suggested.
Journal ArticleDOI
In control of biology: of mice, men and Foxes.
TL;DR: This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans.