P
Patrizia Caporaso
Researcher at University of Rome Tor Vergata
Publications - 7
Citations - 364
Patrizia Caporaso is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 6, co-authored 7 publications receiving 347 citations.
Papers
More filters
Journal ArticleDOI
Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors.
Tiziana Di Pucchio,Lorenzo Pilla,Imerio Capone,Maria Ferrantini,Enrica Montefiore,Francesca Urbani,Roberto Patuzzo,Elisabetta Pennacchioli,Mario Santinami,Agata Cova,Gloria Sovena,Flavio Arienti,Claudia Lombardo,Arianna Lombardi,Patrizia Caporaso,Stefania D'Atri,Paolo Marchetti,Enzo Bonmassar,Giorgio Parmiani,Filippo Belardelli,Licia Rivoltini +20 more
TL;DR: Although further clinical studies are needed to show the adjuvant activity of IFn-alpha, the present data represent an important starting point for considering a new clinical use of IFN-alpha and new immunologic end points, potentially predictive of clinical response.
Journal ArticleDOI
Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155.
Lauretta Levati,Ester Alvino,Elena Pagani,Diego Arcelli,Patrizia Caporaso,Sergio Bondanza,Gianpiero Di Leva,Manuela Ferracin,Stefano Volinia,Enzo Bonmassar,Carlo M. Croce,Stefania D'Atri +11 more
TL;DR: The data further support the finding of altered miRNA expression in melanoma cells and establish for the first time that miRNA-155 is a negative regulator of melanoma cell proliferation and survival.
Journal ArticleDOI
MicroRNA‐155 targets the SKI gene in human melanoma cell lines
Lauretta Levati,Elena Pagani,Sveva Romani,Daniele Castiglia,Eugenia Piccinni,Claudia Covaciu,Patrizia Caporaso,Sergio Bondanza,Francesca Romana Antonetti,Enzo Bonmassar,Fabio Martelli,Ester Alvino,Stefania D'Atri +12 more
TL;DR: The data demonstrate for the first time that SKI is a target of miR‐155 in melanoma, and that impairment of SKI expression is not the leading mechanism involved in the growth‐suppressive effect of mi R‐155 found in this malignancy.
Journal ArticleDOI
A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.
Ester Alvino,Daniele Castiglia,Simona Caporali,Rita Pepponi,Patrizia Caporaso,Pedro Miguel Lacal,Giancarlo Marra,Franziska Fischer,Giovanna Zambruno,Enzo Bonmassar,Joseph Jiricny,Stefania D'Atri +11 more
TL;DR: It is demonstrated that a single cycle of TMZ is sufficient to induce high levels of drug resistance in melanoma clones, principally, but not exclusively, via up-regulation of MGMT expression.
Journal ArticleDOI
Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia
Patrizia Caporaso,Mario Turriziani,Adriano Venditti,Francesco Marchesi,Francesco Marchesi,Francesco Buccisano,Maria Cristina Tirindelli,Ester Alvino,Alberto Garbin,Grazia Tortorelli,Laura Toppo,Enzo Bonmassar,Stefania D'Atri,Sergio Amadori +13 more
TL;DR: This investigation confirms the potential role of triazenes in leukaemia and highlights the contribution of Lomeguatrib in overcoming drug resistance and offers a new approach to control minimal residual disease.