M
Michael Freitag
Researcher at Oregon State University
Publications - 142
Citations - 13475
Michael Freitag is an academic researcher from Oregon State University. The author has contributed to research in topics: Gene & Neurospora crassa. The author has an hindex of 53, co-authored 114 publications receiving 12072 citations. Previous affiliations of Michael Freitag include University of Oregon.
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Journal ArticleDOI
The genome sequence of the filamentous fungus Neurospora crassa
James E. Galagan,Sarah E. Calvo,Katherine A. Borkovich,Eric U. Selker,Nick O. Read,David B. Jaffe,William Fitzhugh,Li-Jun Ma,Serge Smirnov,Seth Purcell,Bushra Rehman,Timothy Elkins,Reinhard Engels,Shunguang Wang,Cydney B. Nielsen,Jonathan Butler,Matthew G. Endrizzi,Dayong Qui,Peter Ianakiev,Deborah Bell-Pedersen,Mary Anne Nelson,Margaret Werner-Washburne,Claude P. Selitrennikoff,John A. Kinsey,Edward L. Braun,Alex Zelter,Alex Zelter,Ulrich Schulte,Gregory O. Kothe,Gregory Jedd,Werner Mewes,Chuck Staben,Edward M. Marcotte,David Greenberg,Alice Roy,Karen Foley,Jerome Naylor,Nicole Stange-Thomann,Robert Barrett,Sante Gnerre,Michael Kamal,Manolis Kamvysselis,Evan Mauceli,Cord Bielke,Stephen Rudd,Dmitrij Frishman,Svetlana Krystofova,Carolyn G. Rasmussen,Robert L. Metzenberg,David D. Perkins,Scott Kroken,Carlo Cogoni,Giuseppe Macino,David E. A. Catcheside,Weixi Li,Robert J. Pratt,Stephen A. Osmani,Colin P.C. DeSouza,Louise Glass,Marc J. Orbach,J. Andrew Berglund,Rodger B. Voelker,Oded Yarden,Michael Plamann,Stephan Seiler,Jay C. Dunlap,Alan Radford,Rodolfo Aramayo,Donald O. Natvig,Lisa A. Alex,Gertrud Mannhaupt,Daniel J. Ebbole,Michael Freitag,Ian T. Paulsen,Matthew S. Sachs,Eric S. Lander,Chad Nusbaum,Bruce W. Birren +77 more
TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Journal ArticleDOI
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Li-Jun Ma,H. Charlotte van der Does,Katherine A. Borkovich,Jeffrey J. Coleman,Marie Josée Daboussi,Antonio Di Pietro,Marie Dufresne,Michael Freitag,Manfred Grabherr,Bernard Henrissat,Petra M. Houterman,Seogchan Kang,Won-Bo Shim,Charles P. Woloshuk,Xiaohui Xie,Jin-Rong Xu,John F. Antoniw,Scott E. Baker,B. H. Bluhm,Andrew Breakspear,Daren W. Brown,Robert A. E. Butchko,Sinéad B. Chapman,Richard M.R. Coulson,Pedro M. Coutinho,Etienne Danchin,Etienne Danchin,Andrew C. Diener,Liane R. Gale,Donald M. Gardiner,Stephen A. Goff,Kim E. Hammond-Kosack,Karen Hilburn,Aurélie Hua-Van,Wilfried Jonkers,Kemal Kazan,Chinnappa D. Kodira,Michael Koehrsen,Lokesh Kumar,Yong-Hwan Lee,Liande Li,Liande Li,John M. Manners,Diego Miranda-Saavedra,Mala Mukherjee,Gyungsoon Park,Jongsun Park,Sook Young Park,Sook Young Park,Robert H. Proctor,Aviv Regev,M. Carmen Ruiz-Roldán,Divya Sain,Sharadha Sakthikumar,Sean M. Sykes,David C. Schwartz,B. Gillian Turgeon,Ilan Wapinski,Olen C. Yoder,Sarah Young,Qiandong Zeng,Shiguo Zhou,James E. Galagan,Christina A. Cuomo,H. Corby Kistler,Martijn Rep +65 more
TL;DR: Comparison of genomes of three phenotypically diverse Fusarium species revealed lineage-specific genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome, putting the evolution of fungal pathogenicity into a new perspective.
Journal ArticleDOI
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
James E. Galagan,Sarah E. Calvo,Christina A. Cuomo,Li-Jun Ma,Jennifer R. Wortman,Serafim Batzoglou,Su-In Lee,Meray Baştürkmen,Christina C. Spevak,John Clutterbuck,Vladimir V. Kapitonov,Jerzy Jurka,Claudio Scazzocchio,Mark L. Farman,Jonathan Butler,Seth Purcell,Steve Harris,Gerhard H. Braus,Oliver W. Draht,Silke Busch,Christophe d'Enfert,Christiane Bouchier,Gustavo H. Goldman,Deborah Bell-Pedersen,Sam Griffiths-Jones,John H. Doonan,Jae-Hyuk Yu,Kay Vienken,Arnab Pain,Michael Freitag,Eric U. Selker,David B. Archer,Miguel A. Peñalva,Berl R. Oakley,Michelle Momany,Toshihiro Tanaka,Toshitaka Kumagai,Kiyoshi Asai,Masayuki Machida,William C. Nierman,David W. Denning,Mark X. Caddick,Michael J. Hynes,Mathieu Paoletti,Reinhard Fischer,Reinhard Fischer,Bruce L. Miller,Paul S. Dyer,Matthew S. Sachs,Stephen A. Osmani,Bruce W. Birren +50 more
TL;DR: The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
Journal ArticleDOI
Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
Katherine A. Borkovich,Lisa A. Alex,Oded Yarden,Michael Freitag,Gloria E. Turner,Nick D. Read,Stephan Seiler,Deborah Bell-Pedersen,John V. Paietta,Nora Plesofsky,Michael Plamann,Marta Goodrich-Tanrikulu,Ulrich Schulte,Gertrud Mannhaupt,Frank E. Nargang,Alan Radford,Claude P. Selitrennikoff,James E. Galagan,Jay C. Dunlap,Jennifer J. Loros,David E. A. Catcheside,Hirokazu Inoue,Rodolfo Aramayo,Michael Polymenis,Eric U. Selker,Matthew S. Sachs,George A. Marzluf,Ian T. Paulsen,Rowland H. Davis,Daniel J. Ebbole,Alex Zelter,Eric R. Kalkman,Rebecca O’Rourke,Frederick J. Bowring,Jane Yeadon,Chizu Ishii,Keiichiro Suzuki,Wataru Sakai,Robert Pratt +38 more
TL;DR: An analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa reveals potential new targets for antifungals as well as loci implicated in human and plant physiology and disease.
Journal ArticleDOI
Deciphering the cryptic genome : genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
Philipp Wiemann,Christian M. K. Sieber,Katharina Walburga von Bargen,Lena Studt,Eva-Maria Niehaus,José J. Espino,Kathleen Huß,Caroline B. Michielse,Sabine Albermann,Dominik Wagner,Sonja Verena Bergner,Lanelle R. Connolly,Andreas Fischer,Gunter Reuter,Karin Kleigrewe,Till Bald,Brenda D. Wingfield,Ron Ophir,Stanley Freeman,Michael Hippler,Kristina M. Smith,Daren W. Brown,Robert H. Proctor,Martin Münsterkötter,Michael Freitag,Hans-Ulrich Humpf,Ulrich Güldener,Bettina Tudzynski +27 more
TL;DR: Combined comparative genomics and genome-wide experimental analyses identified novel genes and secondary metabolites that contribute to the evolutionary success of F. fujikuroi as a rice pathogen.