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Paul B. Fisher
Researcher at Virginia Commonwealth University
Publications - 486
Citations - 35304
Paul B. Fisher is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 80, co-authored 449 publications receiving 31149 citations. Previous affiliations of Paul B. Fisher include Discovery Institute & Columbia University Medical Center.
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Emerging roles of centrosomal amplification and genomic instability in cancer.
TL;DR: In this review, the recent studies investigating genomic instability and aneuploidy in human cancer, centrosome amplification and the role of centrosomal duplication in chromosomal mis-segregetion, and genes implicated in regulating chromosome segregation,Centrosomal amplification and progression in cancer cells are discussed.
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Emerging strategies for the early detection and prevention of head and neck squamous cell cancer
TL;DR: Recent advances in understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches and the potential role of such factors for developing preventive and early diagnostic strategies for H NSCC management is discussed.
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mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.
Praveen Bhoopathi,Nathaniel Lee,Anjan K. Pradhan,Xue-Ning Shen,Swadesh K. Das,Devanand Sarkar,Luni Emdad,Paul B. Fisher +7 more
TL;DR: A novel pathway for mda-7/IL-24-induced caspase-independent apoptosis in neuroblastoma cells is elucidated through modulation of AIF, ATM, and γ-H2AX, which was validated further using two ATM small-molecule inhibitors.
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A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels
Margaret A. Park,Hossein A. Hamed,Clint Mitchell,Nichola Cruickshanks,Rupesh Dash,Jeremy C. Allegood,Igor P. Dmitriev,Gary W. Tye,Besim Ogretmen,Sarah Spiegel,Adly Yacoub,Steven Grant,David T. Curiel,Paul B. Fisher,Paul Dent +14 more
TL;DR: The data indicate that in RCCs, Ad.5/3-mda-7-induced ceramide generation plays a central role in tumor cell killing and inhibition of multiple signaling pathways may have utility in promoting MDA-7/IL-24 lethality in renal cancer.
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Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells.
Irina V. Lebedeva,Zhao-zhong Su,Luni Emdad,A. Kolomeyer,Devanand Sarkar,Shinichi Kitada,Samuel Waxman,John C. Reed,Paul B. Fisher +8 more
TL;DR: Findings support an effective dual-combinatorial approach for the therapy of colorectal cancers that employs a unique cancer-specific suppressor gene (mda-7/IL-24) with targeted inhibition of oncogene (ras) expression.