P
Paul B. Fisher
Researcher at Virginia Commonwealth University
Publications - 486
Citations - 35304
Paul B. Fisher is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 80, co-authored 449 publications receiving 31149 citations. Previous affiliations of Paul B. Fisher include Discovery Institute & Columbia University Medical Center.
Papers
More filters
Journal ArticleDOI
Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene
TL;DR: A gene associated with transformation progression in virus-and oncogene-transformed rat embryo cells, progression elevated gene-3 (PEG-3), has been cloned through the use of subtraction hybridization as mentioned in this paper.
Journal ArticleDOI
Astrocyte Elevated Gene-1: Far More Than Just a Gene Regulated in Astrocytes
TL;DR: The present review critically evaluates what is currently known about AEG-1 and provides new perspectives relative to this intriguing molecule that may provide a rational target for intervening in the cancer phenotype.
Journal ArticleDOI
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Adly Yacoub,Hossein A. Hamed,Jeremy C. Allegood,Clint Mitchell,Sarah Spiegel,Maciej S. Lesniak,Besim Ogretmen,Rupesh Dash,Devanand Sarkar,William C. Broaddus,Steven Grant,David T. Curiel,Paul B. Fisher,Paul Dent +13 more
TL;DR: It is indicated that mda-7/IL-24 induces an endoplasmic reticulum stress response that triggers production of ceramide, Ca(2+), and ROS, which in turn promote glioma cell autophagy and cell death.
Book ChapterDOI
AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis
TL;DR: A review of the current literature on AEG-1/MTDH/LYRIC function relative to signaling changes, interacting partners, and angiogenesis highlights new perspectives of this molecule, indicating its potential as a significant target for the clinical treatment of various cancers and other diseases.
Journal ArticleDOI
Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.
Luni Emdad,Irina V. Lebedeva,Zhao Zhong Su,Pankaj Gupta,Moira Sauane,Rupesh Dash,Steven Grant,Paul Dent,David T. Curiel,Devanand Sarkar,Paul B. Fisher +10 more
TL;DR: This review highlights the current understanding of the molecular and biochemical basis of mda-7/IL-24 antitumor properties and highlights its potential as a viable gene-based therapy for a wide spectrum of primary and advanced cancers.