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Paul B. Fisher
Researcher at Virginia Commonwealth University
Publications - 486
Citations - 35304
Paul B. Fisher is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 80, co-authored 449 publications receiving 31149 citations. Previous affiliations of Paul B. Fisher include Discovery Institute & Columbia University Medical Center.
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Journal Article
Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate
Hongping Jiang,Jian Lin,Shu-Min Young,Neil I. Goldstein,S. Waxman,V. Davila,S. P. Chellappan,Paul B. Fisher +7 more
TL;DR: The results demonstrate that terminal cell differentiation involves a co-ordinate and continuous suppression of a number of cell cycle and growth related genes and results in the development of a novel E2F transcription factor complex not apparent in growth arrested and reversibly differentiated human melanoma cells.
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Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24.
Ping Gao,Xiaolei Sun,Xing Chen,Yanping Wang,Barbara A. Foster,John R. Subjeck,Paul B. Fisher,Xiang-Yang Wang +7 more
TL;DR: Generation of systemic antitumor immunity was shown by enhanced protection against subsequent tumor challenge and improved control of distant tumors, indicating that an improved anticancer efficacy may be achieved by concurrently targeting both tumor and immune compartments.
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PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Margaret A. Park,Adly Yacoub,Devanand Sarkar,Luni Emdad,Mohammed Rahmani,Sarah Spiegel,Constantinos Koumenis,Martin R. Graf,David T. Curiel,Steven Grant,Paul B. Fisher,Paul Dent +11 more
TL;DR: The data demonstrate that GST-MDA-7 induces an ER stress response that, via the induction of autophagy, is causal in the activation of pro-apoptotic pathways that converge on the mitochondrion and ultimately culminate in decreased glioma cell survival.
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Identification and cloning of genes displaying elevated expression as a consequence of metastatic progression in human melanoma cells by rapid subtraction hybridization
TL;DR: Six known genes, 67-kDa laminin receptor (67LR), endothelin receptor B, Na+/K+-ATPase, Ku antigen, interleukin-receptor-associated kinase-1 (IRAK-1) and ribosomal protein RPLA, which may contribute to the complex process of melanoma metastasis are identified.
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Targeting the Immunoregulator SRA/CD204 Potentiates Specific Dendritic Cell Vaccine-Induced T-cell Response and Antitumor Immunity
Huanfa Yi,Chunqing Guo,Xiaofei Yu,Ping Gao,Jie Qian,Daming Zuo,Masoud H. Manjili,Paul B. Fisher,John R. Subjeck,Xiang-Yang Wang +9 more
TL;DR: It is established that downregulating SRA/CD204 strongly enhances DC-mediated antitumor immunity and provides a rationale to enhance DC vaccine potency through SRA /CD204-targeting approaches that can improve clinical outcomes in cancer treatment.