Paul D. Coleman

TL;DR: Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.

TL;DR: The widespread declines in synaptic gene expression in normal aging suggests that function of existing synapses might be impaired, and that a common set of synaptic genes are vulnerable to change in aging and AD.

TL;DR: The epigenetic mechanisms relevant for NSCs and AD etiology are reviewed, and the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, are reviewed.

TL;DR: RNA expression changes in the middle temporal gyrus of Alzheimer's Disease patients by RNA sequencing the whole transcriptome of 8 AD and 8 Non-Demented controls confirmed other published work examining gene expression in the hippocampus of AD patients and suggested a role of these transcripts in altering synaptic and amyloid-β associated pathways.

TL;DR: Applying this approach, it is demonstrated that multiple proteins are unambiguously detected in the same set of cells, regardless of the protein analysis order.