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Elaine Delvaux
Researcher at Arizona State University
Publications - 28
Citations - 1413
Elaine Delvaux is an academic researcher from Arizona State University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 13, co-authored 24 publications receiving 1149 citations. Previous affiliations of Elaine Delvaux include University of Rochester & Biodesign Institute.
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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
TL;DR: Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
Journal ArticleDOI
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation
Diego Mastroeni,Andrew Grover,Elaine Delvaux,Charisse M. Whiteside,Paul D. Coleman,Joseph G. Rogers +5 more
TL;DR: These findings suggest epigenetic dysfunction in AD-vulnerable neurons, and show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases.
Journal ArticleDOI
Epigenetic mechanisms in Alzheimer's disease
Diego Mastroeni,Andrew Grover,Elaine Delvaux,Charisse M. Whiteside,Paul D. Coleman,Joseph G. Rogers +5 more
TL;DR: Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD.
Journal ArticleDOI
Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease.
Diego Mastroeni,Diego Mastroeni,Omar M. Khdour,Elaine Delvaux,Jennifer Nolz,Gary Olsen,Nicole C. Berchtold,Carl W. Cotman,Sidney M. Hecht,Paul D. Coleman,Paul D. Coleman +10 more
TL;DR: The expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects are described.
Journal ArticleDOI
Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Roy Lardenoije,Roy Lardenoije,Janou A. Y. Roubroeks,Janou A. Y. Roubroeks,Ehsan Pishva,Ehsan Pishva,Markus Leber,Holger Wagner,Artemis Iatrou,Adam Smith,Rebecca G. Smith,Lars M. T. Eijssen,Luca Kleineidam,Luca Kleineidam,Luca Kleineidam,Amit Kawalia,Per Hoffmann,Per Hoffmann,Tobias Luck,Steffi G. Riedel-Heller,Frank Jessen,Frank Jessen,Wolfgang Maier,Wolfgang Maier,Michael Wagner,Michael Wagner,René Hurlemann,Gunter Kenis,Muhammad Ali,Muhammad Ali,Antonio del Sol,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Paul D. Coleman,Jonathan Mill,Jonathan Mill,Bart P. F. Rutten,Katie Lunnon,Alfredo Ramirez,Alfredo Ramirez,Daniel L.A. van den Hove,Daniel L.A. van den Hove +42 more
TL;DR: The implication of genome-wide significant differential methylation of OXT, encoding oxytocin, in two independent cohorts indicates it is a promising target for future studies on early biomarkers and novel therapeutic strategies in AD.