D
Daniel L.A. van den Hove
Researcher at University of Würzburg
Publications - 110
Citations - 4701
Daniel L.A. van den Hove is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 34, co-authored 110 publications receiving 3865 citations. Previous affiliations of Daniel L.A. van den Hove include Maastricht University Medical Centre & Maastricht University.
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Journal ArticleDOI
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
TL;DR: Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
Journal ArticleDOI
The epigenetics of aging and neurodegeneration.
Roy Lardenoije,Artemis Iatrou,Gunter Kenis,Konstantinos Kompotis,Harry W.M. Steinbusch,Diego Mastroeni,Paul D. Coleman,Cynthia A. Lemere,Patrick R. Hof,Daniel L.A. van den Hove,Bart P. F. Rutten +10 more
TL;DR: Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.
Journal ArticleDOI
Epigenetic regulation in the pathophysiology of Alzheimer's disease.
Leonidas Chouliaras,Bart P. F. Rutten,Gunter Kenis,Odette Peerbooms,Pieter Jelle Visser,Pieter Jelle Visser,Frans R.J. Verhey,Jim van Os,Harry W.M. Steinbusch,Daniel L.A. van den Hove,Daniel L.A. van den Hove +10 more
TL;DR: It is clear that aging and AD are associated with epigenetic dysregulation at various levels, and data on e.g. twin studies in AD support the notion that epigenetic mechanisms mediate the risk for AD.
Journal ArticleDOI
Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence.
TL;DR: It is demonstrated that maternal fluoxetine exposure reverses the reduction in immobility evident in prenatally stressed adolescent offspring and the decrease in hippocampal cell proliferation and neurogenesis in maternally stress adolescent offspring.
Journal ArticleDOI
Defeat stress in rodents: From behavior to molecules.
Caroline Hammels,Ehsan Pishva,Jochen De Vry,Daniel L.A. van den Hove,Jos Prickaerts,Ruud van Winkel,Jean-Paul Selten,Klaus-Peter Lesch,Nikolaos P. Daskalakis,Harry W.M. Steinbusch,Jim van Os,Gunter Kenis,Bart P. F. Rutten +12 more
TL;DR: The general principle of social defeat stress paradigms are explained, with a strong focus on the resident-intruder model, and the molecular adaptations that are found in animals subjected to defeat stress are provided, with special attention to neural circuits and neuroendocrine signaling.