S
Simon R. Cox
Researcher at University of Edinburgh
Publications - 236
Citations - 10127
Simon R. Cox is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Medicine & Cognition. The author has an hindex of 36, co-authored 192 publications receiving 7055 citations.
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Journal ArticleDOI
DNA methylation age of blood predicts all-cause mortality in later life.
Riccardo E. Marioni,Riccardo E. Marioni,Sonia Shah,Allan F. McRae,Brian H. Chen,Elena Colicino,Sarah E. Harris,Jude Gibson,Anjali K. Henders,Paul Redmond,Simon R. Cox,Alison Pattie,Janie Corley,Lee Murphy,Nicholas G. Martin,Grant W. Montgomery,Andrew P. Feinberg,M. Daniele Fallin,M. Daniele Fallin,Michael L. Multhaup,Andrew E. Jaffe,Roby Joehanes,Roby Joehanes,Joel Schwartz,Allan C. Just,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,John M. Starr,Steve Horvath,Andrea A. Baccarelli,Daniel Levy,Peter M. Visscher,Peter M. Visscher,Naomi R. Wray,Ian J. Deary +36 more
TL;DR: DNA methylation-derived measures of accelerated aging are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors.
Journal ArticleDOI
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Aysu Okbay,Bart M. L. Baselmans,Jan-Emmanuel De Neve,Patrick Turley,Michel G. Nivard,Mark Alan Fontana,S. Fleur W. Meddens,S. Fleur W. Meddens,S. Fleur W. Meddens,Richard Karlsson Linnér,Richard Karlsson Linnér,Richard Karlsson Linnér,Cornelius A. Rietveld,Jaime Derringer,Jacob Gratten,James J. Lee,Jimmy Z. Liu,Ronald de Vlaming,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Jadwiga Buchwald,Alana Cavadino,Alexis C. Frazier-Wood,Nicholas A. Furlotte,Victoria Garfield,Marie Henrike Geisel,Juan R. González,Saskia Haitjema,Robert Karlsson,Sander W. van der Laan,Karl-Heinz Ladwig,Jari Lahti,Sven J. van der Lee,Penelope A. Lind,Tian Liu,Lindsay K. Matteson,Evelin Mihailov,Michael B. Miller,Camelia C. Minică,Ilja M. Nolte,Dennis O. Mook-Kanamori,Peter J. van der Most,Christopher Oldmeadow,Yong Qian,Olli T. Raitakari,Olli T. Raitakari,Rajesh Rawal,Anu Realo,Anu Realo,Rico Rueedi,Rico Rueedi,Börge Schmidt,Albert V. Smith,Evie Stergiakouli,Toshiko Tanaka,Kent D. Taylor,Gudmar Thorleifsson,Juho Wedenoja,Juergen Wellmann,Harm-Jan Westra,Sara M. Willems,Wei Zhao,Najaf Amin,Andrew Bakshi,Sven Bergmann,Sven Bergmann,Gyda Bjornsdottir,Patricia A. Boyle,Samantha Cherney,Simon R. Cox,Gail Davies,Oliver S. P. Davis,Jun Ding,Nese Direk,Peter Eibich,Peter Eibich,Rebecca T. Emeny,Ghazaleh Fatemifar,Jessica D. Faul,Luigi Ferrucci,Andreas J. Forstner,Christian Gieger,Richa Gupta,Tamara B. Harris,Juliette Harris,Elizabeth G. Holliday,Jouke-Jan Hottenga,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Marika Kaakinen,Marika Kaakinen,Eero Kajantie,Eero Kajantie,Ville Karhunen,Ivana Kolcic,Meena Kumari,Lenore J. Launer,Lude Franke,Ruifang Li-Gao,David C. Liewald,Marisa Koini,Anu Loukola,Pedro Marques-Vidal,Grant W. Montgomery,Miriam A. Mosing,Lavinia Paternoster,Alison Pattie,K. Petrovic,Laura Pulkki-Råback,Lydia Quaye,Katri Räikkönen,Igor Rudan,Rodney J. Scott,Jennifer A. Smith,Angelina R. Sutin,Angelina R. Sutin,Maciej Trzaskowski,Maciej Trzaskowski,Anna A. E. Vinkhuyzen,Lei Yu,Delilah Zabaneh,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Lars Bertram,Dorret I. Boomsma,Harold Snieder,Shun-Chiao Chang,Francesco Cucca,Ian J. Deary,Cornelia M. van Duijn,Johan G. Eriksson,Johan G. Eriksson,Ute Bültmann,Eco J. C. de Geus,Patrick J. F. Groenen,Vilmundur Gudnason,Torben Hansen,C.A. Hartman,Claire M. A. Haworth,Caroline Hayward,Andrew C. Heath,David A. Hinds,Elina Hyppönen,Elina Hyppönen,William G. Iacono,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Jaakko Kaprio,Sharon L.R. Kardia,Liisa Keltikangas-Järvinen,Peter Kraft,Laura D. Kubzansky,Terho Lehtimäki,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Andres Metspalu,Melinda Mills,Renée de Mutsert,Albertine J. Oldehinkel,Gerard Pasterkamp,Nancy L. Pedersen,Robert Plomin,Ozren Polasek,Christine Power,Stephen S. Rich,Frits R. Rosendaal,Hester M. den Ruijter,David Schlessinger,Helena Schmidt,Rauli Svento,Reinhold Schmidt,Behrooz Z. Alizadeh,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Tim D. Spector,John M. Starr,Kari Stefansson,Kari Stefansson,Andrew Steptoe,Antonio Terracciano,Antonio Terracciano,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Peter Vollenweider,Gert G. Wagner,Gert G. Wagner,Gert G. Wagner,David R. Weir,Jian Yang,Dalton Conley,George Davey Smith,Albert Hofman,Albert Hofman,Magnus Johannesson,David Laibson,Sarah E. Medland,Michelle N. Meyer,Michelle N. Meyer,Joseph K. Pickrell,Tõnu Esko,Robert F. Krueger,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Philipp Koellinger,Daniel J. Benjamin,Meike Bartels,David Cesarini +216 more
TL;DR: In this paper, the authors conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n= 161,460), and neuroticism(n = 170,911).
Journal ArticleDOI
Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants
Stuart J. Ritchie,Simon R. Cox,Xueyi Shen,Michael V. Lombardo,Michael V. Lombardo,Lianne M. Reus,Clara Alloza,Mathew A. Harris,Helen L Alderson,Stuart Hunter,Emma Neilson,David C. Liewald,Bonnie Auyeung,Heather C. Whalley,Stephen M. Lawrie,Catharine R. Gale,Catharine R. Gale,Mark E. Bastin,Andrew M. McIntosh,Ian J. Deary +19 more
TL;DR: This large-scale study provides a foundation for attempts to understand the causes and consequences of sex differences in adult brain structure and function.
Journal ArticleDOI
Brain age predicts mortality
James H. Cole,Stuart J. Ritchie,Mark E. Bastin,M C Valdés Hernández,S. Muñoz Maniega,Natalie A. Royle,Janie Corley,Alison Pattie,Sarah E. Harris,Qian Zhang,Naomi R. Wray,Paul Redmond,Riccardo E. Marioni,Riccardo E. Marioni,John M. Starr,Simon R. Cox,Joanna M. Wardlaw,David J. Sharp,Ian J. Deary +18 more
TL;DR: This study introduces a clinically-relevant neuroimaging ageing biomarker ‘brain-predicted age’ and demonstrates that combining distinct measurements of biological ageing further helps to determine risk of age-related deterioration and death.
Journal ArticleDOI
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Riccardo E. Marioni,Sonia Shah,Allan F. McRae,Stuart J. Ritchie,Graciela Muniz-Terrera,Sarah E. Harris,Jude Gibson,Paul Redmond,Simon R. Cox,Alison Pattie,Janie Corley,Adele M. Taylor,Lee Murphy,John M. Starr,Steve Horvath,Peter M. Visscher,Naomi R. Wray,Ian J. Deary +17 more
TL;DR: Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration), however, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.