Journal ArticleDOI
Gut microbiota composition correlates with diet and health in the elderly
Marcus J. Claesson,Ian B. Jeffery,Susana Conde,Susan E. Power,Eibhlís M. O'Connor,Siobhán Cusack,Hugh M. B. Harris,M. Coakley,Bhuvaneswari Lakshminarayanan,Orla O'Sullivan,Gerald F. Fitzgerald,Jennifer Deane,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Denis O'Mahony,Denis O'Mahony,Douwe van Sinderen,Martina Wallace,Lorraine Brennan,Catherine Stanton,Catherine Stanton,Julian R. Marchesi,Anthony P. Fitzgerald,Fergus Shanahan,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +28 more
TLDR
The data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.Abstract:
Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.read more
Citations
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Journal ArticleDOI
The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
Journal ArticleDOI
Richness of human gut microbiome correlates with metabolic markers
Trine Nielsen,Junjie Qin,Edi Prifti,Falk Hildebrand,Gwen Falony,Mathieu Almeida,Manimozhiyan Arumugam,Jean-Michel Batto,Sean Kennedy,Pierre Leonard,Junhua Li,Kristoffer Sølvsten Burgdorf,Niels Grarup,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Ivan Brandslund,Henrik Nielsen,Agnieszka S. Juncker,Marcelo Bertalan,Florence Levenez,Nicolas Pons,Simon Rasmussen,Shinichi Sunagawa,Julien Tap,Sebastian Tims,Erwin G. Zoetendal,Søren Brunak,Karine Clément,Karine Clément,Joël Doré,Michiel Kleerebezem,Karsten Kristiansen,Pierre Renault,Thomas Sicheritz-Pontén,Willem M. de Vos,Willem M. de Vos,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Jeroen Raes,Torben Hansen,Torben Hansen,Peer Bork,Jun Wang,S. Dusko Ehrlich,Oluf Pedersen +46 more
TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Journal ArticleDOI
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Journal ArticleDOI
The Human Intestinal Microbiome in Health and Disease
Susan V. Lynch,Oluf Pedersen +1 more
TL;DR: The large majority of studies on the role of the microbiome in the pathogenesis of disease are correlative and preclinical; several have influenced clinical practice.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
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