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Paula Ghaneh
Researcher at University of Liverpool
Publications - 219
Citations - 15603
Paula Ghaneh is an academic researcher from University of Liverpool. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 56, co-authored 204 publications receiving 13631 citations. Previous affiliations of Paula Ghaneh include Royal Liverpool and Broadgreen University Hospital NHS Trust & Royal Liverpool University Hospital.
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Journal ArticleDOI
Biomarkers for early diagnosis of pancreatic cancer.
Claire Jenkinson,Julie Earl,Paula Ghaneh,Christopher Halloran,Alfredo Carrato,William Greenhalf,John P. Neoptolemos,Eithne Costello +7 more
TL;DR: The authors examine the challenges associated with finding new pancreatic cancer diagnostic biomarkers and explore why translation of biomarker research for patient benefit has thus far failed and what advances may lead to improvements in biomarker detection and implementation.
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What Is the Best Way to Identify Malignant Transformation Within Pancreatic IPMN: A Systematic Review and Meta-Analyses
Asma Sultana,Richard J. Jackson,Gilbert Tim,Emma Bostock,Eftychia E. Psarelli,Trevor Cox,Robert Sutton,Paula Ghaneh,Michael Raraty,John P. Neoptolemos,Christopher Halloran +10 more
TL;DR: PET holds the most promise in identifying malignant transformation within an IPMN, and the presence of mural nodule on imaging was the most sensitive whereas raised serum CA19-9 (>37 KU/l) was themost specific feature predictive of malignancy in IPMNs.
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ESPAC-4: A multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma.
John P. Neoptolemos,Daniel H. Palmer,Paula Ghaneh,Juan W. Valle,David Cunningham,Jonathan Wadsley,Tim Meyer,Alan Anthoney,Bengt Glimelius,Stephen Falk,Ralf Segersvärd,Jakob R. Izbicki,Gary Middleton,Paul Ross,Harpreet Wasan,A. C. McDonald,Thomas Crosby,Eftychia E. Psarelli,Pascal Hammel,Markus W. Büchler +19 more
TL;DR: The ESPAC-4 aimed to determine whether combination chemotherapy with GEM/CAP improved survival compared to GEM monotherapy, and the primary endpoint was overall survival.
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New techniques and agents in the adjuvant therapy of pancreatic cancer.
TL;DR: Currently, the best treatment is with 5-fluorouracil with folinic acid, but in the light of ongoing clinical trials, this may be supplanted by gemcitabine as the treatment of choice.
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When is pancreatitis considered to be of biliary origin and what are the implications for management
Nicholas Alexakis,Martin Lombard,Michael Raraty,Paula Ghaneh,Howard Smart,Ian Gilmore,J. Evans,M. Hughes,C. Garvey,Robert Sutton,John P. Neoptolemos +10 more
TL;DR: A number of recent studies have shown that bile crystal analysis, a marker for microlithiasis, increases the yield of positive results over and above endoluminal ultrasonography, and should be considered as part of the modern investigative algorithm.