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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Journal ArticleDOI
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
Paula I. Moreira,Sandra L. Siedlak,Gjumrakch Aliev,Xiongwei Zhu,Adam D. Cash,Mark A. Smith,George Perry +6 more
TL;DR: The clarification of these phenomena can open a new window for understanding the mechanisms underlying neurodegeneration and, consequently, for the development of new therapeutic strategies such as gene therapy and new pharmaceutical formulations with antioxidant and chelating properties.
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Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
TL;DR: The present review aims to discuss the role of physical exercise in the modulation of the mechanisms involved in neuroprotection including the activation of signaling pathways underlying brain protection.
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Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease.
Sónia C. Correia,Renato X. Santos,Maria S. Santos,Gemma Casadesus,Joseph C. LaManna,George Perry,George Perry,Mark A. Smith,Paula I. Moreira +8 more
TL;DR: The results demonstrate that the insulin-resistant brain state that characterizes this rat model of sAD is accompanied by the occurrence of mitochondrial abnormalities reinforcing the validity of this animal model to study sAD pathogenesis and potential therapies.
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Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.
Sónia C. Correia,Cristina Carvalho,Maria S. Santos,Teresa Proença,Elsa Nunes,Ana I. Duarte,Pedro Monteiro,Raquel Seiça,Catarina R. Oliveira,Paula I. Moreira +9 more
TL;DR: Results indicate that met formin protects against diabetes-associated oxidative stress suggesting that metformin could be an effective neuroprotective agent.
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Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease.
Vera F. Monteiro-Cardoso,M. Manuel Oliveira,Tânia Melo,Maria Rosário Domingues,Paula I. Moreira,Elisabete Ferreiro,Francisco Peixoto,Romeu A. Videira +7 more
TL;DR: In contrast to synaptic mitochondria, results support the idea that non-synaptic mitochondria function is preserved at the age of 3 months, and connect specific lipidomic changes with synaptic bioenergetic deficit that may contribute to the progressive synapses loss and the neurodegenerative process that characterizes AD.