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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Journal ArticleDOI
The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.
Inês Marques-Aleixo,Estela Santos-Alves,Paulo J. Oliveira,Paula I. Moreira,José Magalhães,António Ascensão +5 more
TL;DR: This review focuses on the current understanding of the mitochondrial-mediated mechanisms underlying the protective effect of exercise against DOX-induced toxicity, not only limited to the cardiac tissue, but also in other tissues such as skeletal muscle, liver and brain.
Journal ArticleDOI
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
Paula I. Moreira,José B.A. Custódio,Elsa Nunes,Antonio Moreno,Raquel Seiça,Catarina R. Oliveira,Maria S. Santos +6 more
TL;DR: The results indicate that E2 has in general deleterious effects that lead to mitochondrial impairment and since mitochondrial dysfunction is a triggering event of cell degeneration and death, the use of exogenous E2 must be carefully considered.
Journal ArticleDOI
Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
Emanuel Candeias,Ana I. Duarte,Inês Sebastião,Márcia Astrês Fernandes,Ana I. Plácido,Cristina Carvalho,Sónia C. Correia,Renato X. Santos,Raquel Seiça,Manuel A. S. Santos,Catarina R. Oliveira,Paula I. Moreira +11 more
TL;DR: It is hypothesized that sex differentially affects hormone-mediated intracellular signaling pathways in T2D brain, ultimately modulating the risk for neurodegenerative conditions and reinforced the need to establish sex-specific preventive and/or therapeutic approaches and an appropriate time window for the efficient treatment against T1D and AD.
Book ChapterDOI
Mitochondria as potential targets in antidiabetic therapy.
TL;DR: This chapter gives an overview about the effects of diabetes in mitochondrial function of several tissues including the pancreas, skeletal and cardiac muscle, liver, and brain and literature that examined the potential protective effect of insulin, insulin-sensitizing drugs, and mitochondrial-targeted antioxidants.
Journal ArticleDOI
Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study
Samuel Chiquita,Elisa J. Campos,João Castelhano,Mário Ribeiro,José Sereno,Paula I. Moreira,Miguel Castelo-Branco,António F. Ambrósio +7 more
TL;DR: The results show that this animal model shows similar neural changes in the retina and brain visual cortex, i.e., retinal and brain thinning, which support the possibility of using the eye as an additional tool (noninvasive) for early AD diagnosis and therapeutic monitoring.