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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Book ChapterDOI
Unpuzzling the Comorbid Type 2 Diabetes and Hypertension-Related Cognitive Dysfunction and Stroke
Inês Sebastião,Emanuel Candeias,Manuel A. S. Santos,Catarina R. Oliveira,Paula I. Moreira,Ana I. Duarte +5 more
TL;DR: It is conceivable that chronic T2D-related brain insulin resistance and hyperglycemia may crosstalk with an overactivated brain renin-angiotensin-II-aldosterone system (RAAS) further potentiating the hypertension-related injury and culminating in cognitive dysfunction and AD.
Journal ArticleDOI
Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!
TL;DR: In this article, a review of the current knowledge regarding the involvement of hypoxia and HIF signaling in the onset and progression of Alzheimer's disease (AD) pathology is presented.
Journal Article
Therapeutic opportunities in Alzheimer disease: Current concepts
Michael W. Marlatt,Paula I. Moreira,Hyoung Gon Lee,Gemma Casadesus,Rudy J. Castellani,Atsushi Takeda,Akihiko Nunomura,Xiongwei Zhu,George Perry,George Perry,Mark A. Smith +10 more
Book ChapterDOI
Unraveling the Role of Mitochondria in Alzheimer’s Disease: Toward Assembling the Puzzle
TL;DR: The present chapter addresses three distinct but connected pieces of the AD puzzle: how could defects of mitochondrial bioenergetics and dynamics contribute to AD pathology, and could mitochondrial defects promote the disease-defining amyloid-β and tau pathologies, and vice versa.