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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Journal ArticleDOI
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang,Bo Su,Sandra L. Siedlak,Paula I. Moreira,Hisashi Fujioka,Yang Wang,Gemma Casadesus,Xiongwei Zhu +7 more
TL;DR: APP, through amyloid β production, causes an imbalance of mitochondrial fission/fusion that results in mitochondrial fragmentation and abnormal distribution, which contributes to mitochondrial and neuronal dysfunction.
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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Lydia W.S. Finley,Arkaitz Carracedo,Jaewon J. Lee,Amanda Souza,Ainara Egia,Jiangwen Zhang,Julie Teruya-Feldstein,Paula I. Moreira,Sandra M. Cardoso,Clary B. Clish,Pier Paolo Pandolfi,Marcia C. Haigis +11 more
TL;DR: It is shown that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect, and it is found that Sirt3 overexpression represses glycolysis and proliferation in breast cancer cells, providing a metabolic mechanism for tumor suppression.
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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
TL;DR: Evidence indicating that mitochondrial dysfunction has an early and preponderant role in Alzheimer's disease is discussed, and the link between mitochondrial dysfunction and autophagy in Alzheimer’s disease is also discussed.
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Involvement of Oxidative Stress in Alzheimer Disease
Akihiko Nunomura,Rudy J. Castellani,Xiongwei Zhu,Paula I. Moreira,George Perry,Mark A. Smith +5 more
TL;DR: A combination of dietary regimen of low total calorie and rich antioxidant nutrients and maintaining physical and intellectual activities may ultimately prove to be one of the most efficacious strategies for AD prevention.
Journal ArticleDOI
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Stephen C. Cunnane,Eugenia Trushina,Cecilie Morland,Alessandro Prigione,Gemma Casadesus,Zane B. Andrews,M. Flint Beal,Linda H. Bergersen,Roberta Diaz Brinton,Suzanne M. de la Monte,Anne Eckert,Jenni Harvey,Ross Jeggo,Jack H. Jhamandas,Oliver Kann,Clotilde Mannoury la Cour,William Martin,Gilles Mithieux,Paula I. Moreira,Michael P. Murphy,Klaus-Armin Nave,Tal Nuriel,Stéphane H. R. Oliet,Stéphane H. R. Oliet,Frédéric Saudou,Frédéric Saudou,Mark P. Mattson,Russell H. Swerdlow,Millan Mark +28 more
TL;DR: The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.