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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Journal ArticleDOI
Insulin attenuates diabetes-related mitochondrial alterations: a comparative study.
Paula I. Moreira,Anabela P. Rolo,Cristina M. Sena,Raquel Seiça,Catarina R. Oliveira,Maria S. Santos +5 more
TL;DR: Results suggest that insulin treatment attenuates diabetes-induced mitochondrial alterations protecting against the increase in oxidative stress and improving oxidative phosphorylation efficiency.
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The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel
Samuel Chiquita,Ana C. Rodrigues-Neves,Filipa I. Baptista,Rafael Carecho,Paula I. Moreira,Miguel Castelo-Branco,António F. Ambrósio +6 more
TL;DR: This review comprehensively summarizing findings related with structural, functional, cellular, and molecular parameters in the retina reported in both Alzheimer’s disease patients and animal models highlights some inconsistent results in the literature as well as relevant missing gaps in this field.
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Impact of diabetes in blood-testis and blood-brain barriers: resemblances and differences.
TL;DR: The role of BBB and BTB in the control of glucose and metabolic dysfunction caused by diabetes in the brain and seminiferous epithelium is reviewed to highlight new opportunities for the treatment of diabetic complications in brain and male reproductive function.
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Effect of streptozotocin-induced diabetes on rat brain mitochondria.
Paula I. Moreira,Maria S. Santos,Antonio Moreno,Teresa Proença,Raquel Seiça,Catarina R. Oliveira +5 more
TL;DR: It is concluded that STZ‐induced diabetes did not promote brain mitochondrial dysfunction, suggesting that oxidative stress associated with type 1 diabetes is not directly related to mitochondria dysfunction, but probably is related to extramitochondrial factor(s).
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Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α.
Sónia C. Correia,Renato X. Santos,Sandra M. Cardoso,Maria S. Santos,Catarina R. Oliveira,Paula I. Moreira +5 more
TL;DR: It is demonstrated that mitochondrial preconditioning induced by cyanide triggers a protective response mediated by mitochondrial ROS and HIF-1α activation and signaling, which render brain endothelial and neuronal cells resistant against glucotoxicity.