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Paula I. Moreira
Researcher at University of Coimbra
Publications - 280
Citations - 31570
Paula I. Moreira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 70, co-authored 268 publications receiving 26670 citations. Previous affiliations of Paula I. Moreira include Case Western Reserve University & University of Texas at San Antonio.
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Book ChapterDOI
Diabesity and Brain Energy Metabolism: The Case of Alzheimer's Disease.
TL;DR: This chapter will make a brief contextualization about the impact that diabetes and obesity can exert in brain structure and function alongside with a brief survey about the role of insulin in normal brain function, exploring its roles in cognition and brain glucose metabolism.
Journal ArticleDOI
Food deprivation promotes oxidative imbalance in rat brain.
Renato X. Santos,Susana Cardoso,Sónia Silva,Sónia C. Correia,Cristina Carvalho,Joana Crisóstomo,Lisa Rodrigues,C. Amaral,T. Louro,Paulo Matafome,Maria S. Santos,Teresa Proença,Ana I. Duarte,Raquel Seiça,Paula I. Moreira +14 more
TL;DR: The results indicate that food deprivation affects brain oxidative status, which could predispose brain cells to degeneration and death.
Journal ArticleDOI
Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models.
Cláudia Pereira,Paula Agostinho,Paula I. Moreira,Ana I. Duarte,Maria S. Santos,Catarina R. Oliveira +5 more
TL;DR: Results obtained from these in vitro experiences support that additional clinical trials should be carried out using vinpocetine, or vincamine derivative, in order to test its therapeutical or preventive effects in diseases where oxidative stress plays a crucial role.
Journal ArticleDOI
Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress
TL;DR: It is shown that synaptosomes of GK diabetic rats have a lower redox activity, but are less susceptible to the Abeta25-35-induced toxicity.
Journal ArticleDOI
Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors
Judite R M Coimbra,Salete J. Baptista,Teresa C.P. Dinis,M. Manuel Cruz Silva,Paula I. Moreira,Armanda E. Santos,Jorge A. R. Salvador +6 more
TL;DR: This study disclosed new BACE1 inhibitors, proving the utility of combining computational and in vitro approaches for effectively predicting anti-BACE1 agents in the early drug discovery process.