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Paulina Wawrzyniak
Researcher at Swiss Institute of Allergy and Asthma Research
Publications - 32
Citations - 2755
Paulina Wawrzyniak is an academic researcher from Swiss Institute of Allergy and Asthma Research. The author has contributed to research in topics: Tight junction & Inflammation. The author has an hindex of 18, co-authored 26 publications receiving 1869 citations.
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Journal ArticleDOI
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Mübeccel Akdis,Alar Aab,Can Altunbulakli,Kursat A Azkur,Rita Costa,Reto Crameri,Su Duan,Thomas Eiwegger,Andrzej Eljaszewicz,Ruth Ferstl,Remo Frei,Mattia Garbani,Anna Głobińska,Lena Hess,Carly Huitema,Terufumi Kubo,Zsolt István Komlósi,Patricia Konieczna,Nóra Kovács,Umut Can Kucuksezer,Norbert Meyer,Hideaki Morita,Judith Olzhausen,Liam O'Mahony,Marija Pezer,Moira Prati,Ana Rebane,Claudio Rhyner,Arturo Rinaldi,Milena Sokolowska,Barbara Stanic,Kazunari Sugita,Angela Treis,Willem van de Veen,Kerstin Wanke,Marcin Wawrzyniak,Paulina Wawrzyniak,Oliver F. Wirz,Josefina Zakzuk,Cezmi A. Akdis +39 more
TL;DR: Recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons are reviewed and their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases are discussed.
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Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4
Michael B. Soyka,Paulina Wawrzyniak,Thomas Eiwegger,Thomas Eiwegger,David Holzmann,Angela Treis,Kerstin Wanke,Jeannette I. Kast,Cezmi A. Akdis +8 more
TL;DR: The disruption of epithelial integrity by IFN-γ and IL-4 in vitro indicates a possible role for these proinflammatory cytokines in the pathogenesis of patients with CRS.
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Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Urszula Radzikowska,Urszula Radzikowska,Mei Ding,Mei Ding,Ge Tan,Ge Tan,Damir Zhakparov,Yaqi Peng,Paulina Wawrzyniak,Ming Wang,Shuo Li,Hideaki Morita,Can Altunbulakli,Matthias Reiger,Avidan U. Neumann,Avidan U. Neumann,Nonhlanhla Lunjani,Claudia Traidl-Hoffmann,Kari C. Nadeau,Liam O'Mahony,Liam O'Mahony,Cezmi A. Akdis,Milena Sokolowska +22 more
TL;DR: The aim of this study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19.
Journal ArticleDOI
Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression.
Brecht Steelant,Ricard Farré,Paulina Wawrzyniak,Jochen Belmans,Emily Dekimpe,Hanne Vanheel,Laura Van Gerven,Inge Kortekaas Krohn,Dominique Bullens,Jan Ceuppens,Cezmi A. Akdis,Guy E. Boeckxstaens,Sven Seys,Peter Hellings +13 more
TL;DR: In this article, the expression, function, and regulation of tight junction (TJ) defects in the nasal epithelium of patients with house dust mite (HDM) induced AR and in an HDM-induced murine model of allergic airway disease were investigated.
Journal ArticleDOI
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients.
Kazunari Sugita,Kazunari Sugita,Catherine A. Steer,Itziar Martinez-Gonzalez,Can Altunbulakli,Hideaki Morita,Francesc Castro-Giner,Francesc Castro-Giner,Terufumi Kubo,Paulina Wawrzyniak,Beate Rückert,Katsuko Sudo,Susumu Nakae,Susumu Nakae,Kenji Matsumoto,Liam O'Mahony,Mübeccel Akdis,Fumio Takei,Cezmi A. Akdis +18 more
TL;DR: It is demonstrated that ILC2s are responsible for bronchial epithelial TJ barrier leakiness through IL‐13, highlighting an essential mechanism in asthma pathogenesis.