K
Kazunari Sugita
Researcher at Tottori University
Publications - 173
Citations - 3253
Kazunari Sugita is an academic researcher from Tottori University. The author has contributed to research in topics: Medicine & Mycosis fungoides. The author has an hindex of 24, co-authored 162 publications receiving 2644 citations. Previous affiliations of Kazunari Sugita include Kyoto University & Swiss Institute of Allergy and Asthma Research.
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Journal ArticleDOI
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Mübeccel Akdis,Alar Aab,Can Altunbulakli,Kursat A Azkur,Rita Costa,Reto Crameri,Su Duan,Thomas Eiwegger,Andrzej Eljaszewicz,Ruth Ferstl,Remo Frei,Mattia Garbani,Anna Głobińska,Lena Hess,Carly Huitema,Terufumi Kubo,Zsolt István Komlósi,Patricia Konieczna,Nóra Kovács,Umut Can Kucuksezer,Norbert Meyer,Hideaki Morita,Judith Olzhausen,Liam O'Mahony,Marija Pezer,Moira Prati,Ana Rebane,Claudio Rhyner,Arturo Rinaldi,Milena Sokolowska,Barbara Stanic,Kazunari Sugita,Angela Treis,Willem van de Veen,Kerstin Wanke,Marcin Wawrzyniak,Paulina Wawrzyniak,Oliver F. Wirz,Josefina Zakzuk,Cezmi A. Akdis +39 more
TL;DR: Recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons are reviewed and their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases are discussed.
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CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.
Kenji Kabashima,Noriko Shiraishi,Kazunari Sugita,Tomoko Mori,Ayako Onoue,Miwa Kobayashi,Jun-ichi Sakabe,Ryutaro Yoshiki,Hirokazu Tamamura,Nobutaka Fujii,Kayo Inaba,Yoshiki Tokura +11 more
TL;DR: It is demonstrated that CXCL12-CXCR4 engagement on cutaneous DCs plays a crucial role in the initiation of skin immune response by enhancing cutaneousDC migration.
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Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients.
Kazunari Sugita,Kazunari Sugita,Catherine A. Steer,Itziar Martinez-Gonzalez,Can Altunbulakli,Hideaki Morita,Francesc Castro-Giner,Francesc Castro-Giner,Terufumi Kubo,Paulina Wawrzyniak,Beate Rückert,Katsuko Sudo,Susumu Nakae,Susumu Nakae,Kenji Matsumoto,Liam O'Mahony,Mübeccel Akdis,Fumio Takei,Cezmi A. Akdis +18 more
TL;DR: It is demonstrated that ILC2s are responsible for bronchial epithelial TJ barrier leakiness through IL‐13, highlighting an essential mechanism in asthma pathogenesis.
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IL-23 from Langerhans Cells Is Required for the Development of Imiquimod-Induced Psoriasis-Like Dermatitis by Induction of IL-17A-Producing γδ T Cells
Ryutaro Yoshiki,Kenji Kabashima,Tetsuya Honda,Satoshi Nakamizo,Yu Sawada,Kazunari Sugita,Haruna Yoshioka,Shun Ohmori,Bernard Malissen,Yoshiki Tokura,Motonobu Nakamura +10 more
TL;DR: Results suggest that LCs are required for the development of psoriasis-like lesions induced by IMQ in mice, and reduce levels of Th17-related cytokines in IMQ-treated skin lesions.
Journal ArticleDOI
Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin
Kazunari Sugita,Kenji Kabashima,Kenji Atarashi,Takatoshi Shimauchi,Masakazu Kobayashi,Yoshiki Tokura +5 more
TL;DR: It is demonstrated that although the direct effect of CpG on LCs is minimal, LC function can be up‐regulated indirectly by cytokines released by CpPG‐stimulated keratinocytes, implying that innate immunity evoked by TLR ligation of keratinocyte enhances acquired immunity comprising LCs and T cells.