P
Pavan K. Vaddady
Researcher at University of Tennessee Health Science Center
Publications - 8
Citations - 329
Pavan K. Vaddady is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Pharmacodynamics & Pharmacokinetics. The author has an hindex of 4, co-authored 6 publications receiving 291 citations.
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Journal ArticleDOI
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
Journal ArticleDOI
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.
Jianjun Chen,Zhao Wang,Chien-Ming Li,Chien-Ming Li,Yan Lu,Pavan K. Vaddady,Bernd Meibohm,James T. Dalton,James T. Dalton,Duane D. Miller,Duane D. Miller,Wei Li +11 more
TL;DR: In vivo results indicated that 5cb was more effective than DTIC in inhibiting melanoma xenograph tumor growth and the results suggest that the novel ABI compounds may be developed to effectively treat drug-resistant tumors.
Journal ArticleDOI
In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.
TL;DR: An introduction to in vitro PK/PD models and their application as critical tools in evaluating anti-TB drugs is provided and the related mathematical modeling approaches of time–kill data are discussed.
Journal ArticleDOI
Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.
Pavan K. Vaddady,Ashit Trivedi,Chetan Rathi,Dora B. Madhura,Jiuyu Liu,Richard E. Lee,Bernd Meibohm +6 more
TL;DR: The PK/PD based analysis of the in vitro pharmacologic killing profile of spectinamides 1599 and 1445 on mycobacteria provided valuable insights that contributed to lead candidate selection and preclinical development of these compounds.
Reference EntryDOI
Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics of Protein Therapeutics
Pavan K. Vaddady,Bernd Meibohm +1 more
TL;DR: The relevance of PK and PD affecting the efficacy, safety, and use of protein therapeutics is focused on, and different ways a protein molecule takes to reach its target tissue are explored.