K
Katharina Brandl
Researcher at University of Montana
Publications - 53
Citations - 3246
Katharina Brandl is an academic researcher from University of Montana. The author has contributed to research in topics: Receptor & Curriculum. The author has an hindex of 24, co-authored 46 publications receiving 2671 citations. Previous affiliations of Katharina Brandl include University of Regensburg & Memorial Sloan Kettering Cancer Center.
Papers
More filters
Journal ArticleDOI
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
Katharina Brandl,George Plitas,Coralia N. Mihu,Coralia N. Mihu,Carles Ubeda,Ting Jia,Martin Fleisher,Bernd Schnabl,Bernd Schnabl,Ronald P. DeMatteo,Eric G. Pamer,Eric G. Pamer +11 more
TL;DR: It is demonstrated that antibiotic treatment of mice notably downregulates intestinal expression of RegIIIγ, a secreted C-type lectin that kills Gram-positive bacteria, including VRE, providing a potential therapeutic approach to reduce colonization and infection by antibiotic-resistant microbes.
Journal ArticleDOI
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Yi Duan,Yi Duan,Cristina Llorente,Cristina Llorente,Sonja Lang,Katharina Brandl,Huikuan Chu,Lu Jiang,Lu Jiang,Richard C. White,Thomas H. Clarke,Kevin Nguyen,Manolito Torralba,Yan Shao,Jinyuan Liu,Adriana Hernandez-Morales,Lauren Lessor,Imran R Rahman,Yukiko Miyamoto,Melissa Ly,Bei Gao,Weizhong Sun,Roman Kiesel,Felix Hutmacher,Suhan Lee,Meritxell Ventura-Cots,Francisco Bosques-Padilla,Elizabeth C. Verna,Juan G. Abraldes,Robert S. Brown,Victor Vargas,José Altamirano,Juan Caballería,Debbie L. Shawcross,Samuel B. Ho,Samuel B. Ho,Alexandre Louvet,Michael R. Lucey,Philippe Mathurin,Guadalupe Garcia-Tsao,Ramon Bataller,Xin M. Tu,Lars Eckmann,Wilfred A. van der Donk,Ry Young,Trevor D. Lawley,Peter Stärkel,David T. Pride,Derrick E. Fouts,Bernd Schnabl,Bernd Schnabl +50 more
TL;DR: It is shown that bacteriophages can specifically target cytolytic E. faecalis, which provides a method for precisely editing the intestinal microbiota, and is linked with more severe clinical outcomes and increased mortality in patients with alcoholic hepatitis.
Journal ArticleDOI
MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
TL;DR: It is shown that clearance of L. monocytogenes from the lumen of the distal small intestine is impaired in MyD88−/− mice, and experiments with bone marrow chimeric mice reveal that MyD 88-mediated signals in nonhematopoietic cells induce RegIIIγ expression in the small intestine, thereby enhancing bacterial killing.
Journal ArticleDOI
Additive Roles for MCP-1 and MCP-3 in CCR2-Mediated Recruitment of Inflammatory Monocytes during Listeria monocytogenes Infection
Ting Jia,Natalya V. Serbina,Katharina Brandl,Maggie X. Zhong,Ingrid Leiner,Israel F. Charo,Eric G. Pamer,Eric G. Pamer +7 more
TL;DR: It is shown that L. monocytogenes infection rapidly induces MCP-3 in tissue culture macrophages and in serum, spleen, liver, and kidney following in vivo infection, suggesting that cytosolic innate immune detection mechanisms trigger chemokine production.
Journal ArticleDOI
Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice
Phillipp Hartmann,Peng Chen,Hui J. Wang,Lirui Wang,Declan F. McCole,Katharina Brandl,Peter Stärkel,Clara Belzer,Claus Hellerbrand,Hidekazu Tsukamoto,Hidekazu Tsukamoto,Samuel B. Ho,Samuel B. Ho,Bernd Schnabl +13 more
TL;DR: Muc2−/− mice are protected from intestinal bacterial overgrowth and dysbiosis in response to alcohol feeding, and lower amounts of bacterial products such as endotoxin translocate into the systemic circulation, decreasing liver disease.