M
Michael Chiorazzi
Researcher at National Institutes of Health
Publications - 17
Citations - 4219
Michael Chiorazzi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 10, co-authored 13 publications receiving 4020 citations. Previous affiliations of Michael Chiorazzi include Rockefeller University.
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Journal ArticleDOI
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
Sandeep S. Dave,George E. Wright,Bruce K. Tan,Andreas Rosenwald,Andreas Rosenwald,Randy D. Gascoyne,Wing C. Chan,Richard I. Fisher,Rita M. Braziel,Lisa M. Rimsza,Thomas M. Grogan,Thomas P. Miller,Michael LeBlanc,Timothy C. Greiner,Dennis D. Weisenburger,James C. Lynch,Julie M. Vose,James O. Armitage,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Jan Delabie,Joseph M. Connors,Peter M. Lansdorp,Qin Ouyang,T. Andrew Lister,Andrew Davies,Andrew J. Norton,H. Konrad Muller-Hermelink,German Ott,Elias Campo,Emilio Montserrat,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Liming Yang,John Powell,Hong Zhao,Neta Goldschmidt,Michael Chiorazzi,Louis M. Staudt +40 more
TL;DR: The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis.
Journal ArticleDOI
Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma
Andreas Rosenwald,George E. Wright,Karen Leroy,Xin-You Yu,Philippe Gaulard,Randy D. Gascoyne,Wing C. Chan,Tong Zhao,Corinne Haioun,Timothy C. Greiner,Dennis D. Weisenburger,James C. Lynch,Julie M. Vose,James O. Armitage,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Jan Delabie,Elias Campo,Emili Montserrat,Armando López-Guillermo,German Ott,H. Konrad Muller-Hermelink,Joseph M. Connors,Rita M. Braziel,Thomas M. Grogan,Thomas M. Grogan,Richard I. Fisher,Richard I. Fisher,Thomas P. Miller,Thomas P. Miller,Michael LeBlanc,Michael LeBlanc,Michael Chiorazzi,Hong-Bo Zhao,Liming Yang,John Powell,Wyndham H. Wilson,Elaine S. Jaffe,Richard Simon,Richard D. Klausner,Louis M. Staudt +41 more
TL;DR: Gene expression profiling strongly supported a relationship between PMBL and Hodgkin lymphoma: over one third of the genes that were more highly expressed in PMBL than in other DLBCLs were also characteristically expressed in Hodgkinymphoma cells.
Journal ArticleDOI
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Andreas Rosenwald,George E. Wright,Adrian Wiestner,Wing C. Chan,Wing C. Chan,Joseph M. Connors,Joseph M. Connors,Elias Campo,Elias Campo,Randy D. Gascoyne,Randy D. Gascoyne,Thomas M. Grogan,Thomas M. Grogan,H. Konrad Muller-Hermelink,H. Konrad Muller-Hermelink,Erlend B. Smeland,Erlend B. Smeland,Michael Chiorazzi,Jena M. Giltnane,Elaine M. Hurt,Hong Zhao,Lauren Averett,Sarah E. Henrickson,Liming Yang,John Powell,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Richard D. Klausner,Emilio Montserrat,Emilio Montserrat,Francesc Bosch,Francesc Bosch,Timothy C. Greiner,Dennis D. Weisenburger,Dennis D. Weisenburger,Warren G. Sanger,Bhavana J. Dave,James C. Lynch,James C. Lynch,Julie M. Vose,James O. Armitage,Richard I. Fisher,Richard I. Fisher,Thomas P. Miller,Thomas P. Miller,Michael LeBlanc,Michael LeBlanc,German Ott,German Ott,Stein Kvaløy,Stein Kvaløy,Harald Holte,Harald Holte,Jan Delabie,Jan Delabie,Louis M. Staudt +56 more
TL;DR: A quantitative model of the aberrant cell cycle regulation in MCL is proposed that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.
Journal ArticleDOI
Cyclin D1-negative mantle cell lymphoma : a clinicopathologic study based on gene expression profiling
Kai Fu,Dennis D. Weisenburger,Timothy C. Greiner,Sandeep S. Dave,George E. Wright,Andreas Rosenwald,Michael Chiorazzi,Javeed Iqbal,Stefan Gesk,Reiner Siebert,Daphne de Jong,Elaine S. Jaffe,Wyndham H. Wilson,Jan Delabie,German Ott,Bhavana J. Dave,Warren G. Sanger,Lynette M. Smith,Lisa M. Rimsza,Rita M. Braziel,H. Konrad Muller-Hermelink,Elias Campo,Randy D. Gascoyne,Louis M. Staudt,Wing C. Chan +24 more
TL;DR: Cases of cyclin D1-negative MCL do exist and are part of the spectrum of MCL, and up-regulation ofcyclin D2 or D3 may substitute for cyclinD1 in the pathogenesis of M CL.
Journal ArticleDOI
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.
Adrian Wiestner,Mahsa Tehrani,Michael Chiorazzi,George E. Wright,Federica Gibellini,Kazutaka Nakayama,Hui Liu,Andreas Rosenwald,H. Konrad Muller-Hermelink,German Ott,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,Julie M. Vose,James O. Armitage,Randy D. Gascoyne,Joseph M. Connors,Elias Campo,Emilio Montserrat,Francesc Bosch,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Jan Delabie,Richard I. Fisher,Thomas M. Grogan,Thomas P. Miller,Wyndham H. Wilson,Elaine S. Jaffe,Louis M. Staudt +29 more
TL;DR: It is concluded that alterations of CCND1 3'UTR structure can significantly increase its oncogenic effect and worsen the clinical course of MCL patients.