P
Peter Thielen
Researcher at Johns Hopkins University Applied Physics Laboratory
Publications - 51
Citations - 3266
Peter Thielen is an academic researcher from Johns Hopkins University Applied Physics Laboratory. The author has contributed to research in topics: Unfolded protein response & Virus. The author has an hindex of 18, co-authored 45 publications receiving 2404 citations. Previous affiliations of Peter Thielen include Johns Hopkins University & Harvard University.
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Journal ArticleDOI
Bracken: estimating species abundance in metagenomics data
TL;DR: Bracken (Bayesian Reestimation of Abundance after Classification with KrakEN) uses the taxonomic assignments made by Kraken, a very fast read-level classifier, along with information about the genomes themselves to estimate abundance at the species level, the genus level, or above.
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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz,Peter Thielen,Soledad Matus,Melissa Nassif,Felipe A. Court,Roberta Kiffin,Gabriela Martínez,Ana Maria Cuervo,Robert H. Brown,Laurie H. Glimcher +9 more
TL;DR: The results reveal a new function of XBP-1 in the control of autophagy and indicate critical cross-talk between these two signaling pathways that can provide protection against neurodegeneration.
Journal ArticleDOI
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
Fernanda Lisbona,Diego Rojas-Rivera,Peter Thielen,Sebastián Zamorano,Derrick J. Todd,Fabio Martinon,Alvaro Glavic,Christina L. Kress,Jonathan H. Lin,Peter Walter,John C. Reed,Laurie H. Glimcher,Claudio Hetz,Claudio Hetz +13 more
TL;DR: A role for BI-1 is suggested in early adaptive responses against ER stress that contrasts with its known downstream function in apoptosis, which is known to be regulated by XBP-1.
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Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
Rene L. Vidal,Alicia Figueroa,Felipe A. Court,Peter Thielen,Claudia Molina,Craig Wirth,Benjamin Caballero,Roberta Kiffin,Juan Segura-Aguilar,Ana Maria Cuervo,Laurie H. Glimcher,Claudio Hetz,Claudio Hetz +12 more
TL;DR: Examination of the expression of two main UPR transcription factors in full-length mutant Huntingtin (mHtt) transgenic mice provided strong evidence supporting an involvement of XBP1 in HD pathogenesis probably due to an ER stress-independent mechanism involving the control of FoxO1 and autophagy levels.
Journal ArticleDOI
Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells
Yang Hu,Yang Hu,Kevin K. Park,Kevin K. Park,Liu Yang,Xin Wei,Qiang Yang,Kin-Sang Cho,Peter Thielen,Ann-Hwee Lee,Romain Cartoni,Laurie H. Glimcher,Dong Feng Chen,Dong Feng Chen,Zhigang He +14 more
TL;DR: In this article, the authors demonstrate that axotomy induces differential activation of distinct pathways of the unfolded protein response in axotomized retinal ganglion cells (RGCs) and their distinct effects on neuronal cell death are also observed in RGCs with other types of axonal insults, such as vincristine treatment and intraocular pressure elevation.