P
Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
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Journal ArticleDOI
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chin Chiang,Ying Litingtung,Eric Lee,Keith E. Young,Jeffrey L Corden,Heiner Westphal,Philip A. Beachy +6 more
TL;DR: Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
TL;DR: It is shown that cyclopamine can reverse the retention of partially misfolded Smo in the endoplasmic reticulum through binding-mediated effects on protein conformation, which suggests a role for small molecules in the physiological regulation of Smo.
Journal ArticleDOI
The Hedgehog and Wnt signalling pathways in cancer
Jussi Taipale,Philip A. Beachy +1 more
TL;DR: Evidence suggesting that tumorigenesis associated with pathway activation may result from mis-specification of cells towards stem-cell or stem cell-like fates is reviewed.
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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
TL;DR: It is reported that cholesterol is the lipophilic moiety covalently attached to the amino- terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase.
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale,James K. Chen,Michael K. Cooper,Baolin Wang,Randall K. Mann,Ljiljana Milenkovic,Matthew P. Scott,Philip A. Beachy +7 more
TL;DR: It is shown that the plant-derived teratogen cyclopamine, which inhibits the Hh response, is a potential ‘mechanism-based’ therapeutic agent for treatment of these tumours.