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Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
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Journal ArticleDOI
Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
Kyle M. Loh,Angela Chen,Pang Wei Koh,Tianda Z. Deng,Rahul Sinha,Jonathan M. Tsai,Amira A. Barkal,Kimberle Shen,Rajan Jain,Rachel M. Morganti,Ng Shyh-Chang,Nathaniel B. Fernhoff,Benson M. George,Gerlinde Wernig,Rachel E.A. Salomon,Zhenghao Chen,Hannes Vogel,Jonathan A. Epstein,Anshul Kundaje,William S. Talbot,Philip A. Beachy,Lay Teng Ang,Irving L. Weissman +22 more
TL;DR: The extrinsic signals controlling each binary lineage decision were defined, enabling us to logically block differentiation toward unwanted fates and rapidly steer pluripotent stem cells toward 80%-99% pure human mesodermal lineages at most branchpoints.
Journal ArticleDOI
Segmental distribution of bithorax complex proteins during Drosophila development
TL;DR: Wild-type and mutant distributions of the segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences.
Journal ArticleDOI
Novel Lipid Modifications of Secreted Protein Signals
Randall K. Mann,Philip A. Beachy +1 more
TL;DR: The cellular mechanisms that have evolved to handle lipidated Hh proteins in the spatial deployment of the signal in developing tissues are discussed and the more recent findings that implicate palmitate modification as an important feature of Wnt signaling proteins are discussed.
Journal ArticleDOI
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
TL;DR: It is demonstrated that one of two murine homologs, mDispA, can rescue disp function in Drosophila and is essential for all Hh patterning activities examined in the early mouse embryo.
Journal ArticleDOI
Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
James Kim,Blake T. Aftab,Blake T. Aftab,Jean Y. Tang,Jean Y. Tang,Daniel H. Kim,Alexander Lee,Alexander Lee,Melika Rezaee,Jynho Kim,Baozhi Chen,Emily M. King,Alexandra Borodovsky,Gregory J. Riggins,Ervin H. Epstein,Philip A. Beachy,Charles M. Rudin +16 more
TL;DR: It is reported that itraconazole and arsenic trioxide, two agents in clinical use that inhibit Hedgehog signaling by mechanisms distinct from that of current Smoothened antagonists, retain inhibitory activity in vitro in the context of all reported resistance-conferring Smothened mutants and GLI2 overexpression.