P
Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
Jeffery A. Porter,Doris P. von Kessler,Stephen C. Ekker,Keith E. Young,John J. Lee,Kevin Moses,Philip A. Beachy +6 more
TL;DR: The site of autoproteolytic cleavage is identified and found that it is broadly conserved throughout the hedgehog family, and it is shown here that the N product is the active species in both local and long-range signalling.
Journal ArticleDOI
Induction of midbrain dopaminergic neurons by Sonic hedgehog
Mary Hynes,Jeffery A. Porter,Chin Chiang,David C. Chang,Marc Tessier-Lavigne,Philip A. Beachy,Arnon Rosenthal +6 more
TL;DR: It is shown that the amino-terminal product of Sonic hedgehog autoproteolysis (SHH-N), an inductive signal expressed by floor plate cells, can induce dopaminergic neurons in vitro and provides the basis for a potential cell transplantation therapy for Parkinson's disease.
Journal ArticleDOI
Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells
Lawrence G. Lum,Shenqin Yao,Brian A. Mozer,Alessandra Cecilia Rovescalli,Doris P. von Kessler,Marshall W. Nirenberg,Philip A. Beachy +6 more
TL;DR: This work used RNA interference and a quantitative cultured cell assay to systematically screen functional roles of all kinases and phosphatases and subsequently 43% of predicted Drosophila genes were identified as Hh pathway components.
Journal ArticleDOI
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
Jeffery A. Porter,Stephen C. Ekker,Woo Jin Park,Doris P. von Kessler,Keith E. Young,Chien Huan Chen,Yong Ma,Amina S. Woods,Robert J. Cotter,Eugene V. Koonin,Philip A. Beachy +10 more
TL;DR: It is demonstrated that truncated unprocessed amino-terminal protein causes embryonic mispatterning, even when expression is localized to cells that normally express Hh, thus suggesting a role for autoprocessing in spatial regulation of hh signaling.
Journal ArticleDOI
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster
Welcome Bender,Michael Akam,François Karch,Philip A. Beachy,Mark Peifer,Pierre Spierer,Edward B. Lewis,David S. Hogness +7 more
TL;DR: The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here.