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Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
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Method of using hedgehog polypeptides to regulate neuronal cell growth
TL;DR: In this paper, two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or Nterminal and C-terminal fragments, respectively, are derived after specific cleavage at a Gly↓Cys Phe site recognized by the autoproteolytic domain in the native protein.
Journal ArticleDOI
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets
Jia Zhao,Gefei Wang,Jingsi Ming,Zhixiang Lin,Yan Wang,Snigdha Agarwal,Aditi Agrawal,Ahmad Al-Moujahed,Megan A. Albertelli,Paul Allegakoen,Thomas J Ambrosi,Jane Antony,Steven E. Artandi,Fabienne Aujard,Kyle Awayan,Ankit Baghel,Isaac Bakerman,Trygve E. Bakken,Jalal K Baruni,Philip A. Beachy,Biter Bilen,Olga B. Botvinnik,Scott D. Boyd,Deviana Burhan,Kerriann M. Casey,Charles Chan,Charles B. Chang,Stephen Chang,Ming Chen,Michael F. Clarke,Sheela Crasta,Rebecca N Culver,Jessica D’Addabbo,Spyros Darmanis,Roozbeh Dehghannasiri,Songlin Ding,Connor Duffy,Jacques Epelbaum,F. Hernan Espinoza,Camille Ezran,Jean Farup,James E. Ferrell,Hannah K. Frank,Margaret Fuller,Astrid Gillich,Elias Godoy,Dita Gratzinger,Lisbeth A. Guethlein,Yan Hang,Kazuteru Hasegawa,Rebecca D. Hodge,Malachia Hoover,Franklin W. Huang,Kerwyn Casey Huang,Shelly Huynh,Taichi Isobe,Carly Israel,SoRi Jang,Qiuyu Jing,Robert C. Jones,Jengmin Kang,Caitlin J. Karanewsky,Jim Karkanias,Justus M. Kebschull,Aaron M. Kershner,Lily An Kim,Seung K. Kim,Eliana Kirk,Winston Koh,Silvana Konermann,W. Kong,Mark A. Krasnow,Christin S. Kuo,Corinne Lautier,Song E. Lee,Ed S. Lein,Rebecca Lewis,Peng Li,Shen-yu Lin,Shixuan Liu,Yin Liu,Gabrielle Loeb,Jonathan Z. Long,Wan Jin Lu,Katherine L. Lucot,Liqun Luo,Aaron McGeever,Ross J. Metzger,Thomas J. Montine,Antoine de Morrée,Maurizio Morri,Karim Mrouj,Shravani Mukherjee,Ahmad N. Nabhan,Saba Nafees,Norma F. Neff,Patrick Neuhöfer,Patricia T. Nguyen,Jennifer Okamoto,Julia Eve Olivieri,Youcef Ouadah,H. H. Paine,Peter Parham,Jozeph L. Pendleton,Lolita Penland,Martine Perret,Angela Oliveira Pisco,Zhenzhong Qi,Stephen R. Quake,Ute Radespiel,Thomas A. Rando,Hajanirina N Ravelonjanahary,Andriamahery Razafindrakoto,Julia Salzman,Nicholas Schaum,Robert L. Schopler,Bronwyn Scott,Liza J. Shapiro,Hosu Sin,Rahul P. Sinha,Rene Sit,Geoff Stanley,Lubert Stryer,Varun R. Subramaniam,Aditi Swarup,Weilun Tan,Alexander J. Tarashansky,Aris Taychameekiatchai,Jérémy Terrien,Kyle J. Travaglini,Andoni Urtasun,V. Sivakamasundari,Avin Veerakumar,Venkata N. P. Vemuri,Jean-Michel Verdier,Iwijn De Vlaminck,Douglas Vollrath,Bo Wang,Bruce Wang,Michael F. Z. Wang,Sheng Wang,James E. Webber,Hannah N.W. Weinstein,Irving L. Weissman,Amanda L Wiggenhorn,Cathy V. Williams,Patricia A. Wright,Albert Y. Wu,Angela Ruohao Wu,Tony Wyss-Coray,Baoqing Xiang,Jiamei Yan,Jinxurong Yang,Anne D. Yoder,Brian Yu,Andrea R. Yung,Yue Zhang,Zicheng Zhao,Can Yang +158 more
TL;DR: In this paper , a unified framework of adversarial domain translation is proposed to learn harmonized representations of datasets, which achieves better performance for preserving biological variation during integration while achieving the integration of millions of cells, in minutes, with low memory consumption.
Proceedings ArticleDOI
Abstract LB-223: An open-label, exploratory phase II study of oral itraconazole for the treatment of basal cell carcinoma
Daniel H. Kim,James Kim,Katrina Spaunhurst,Javier Montoya,Kalyani Chandra,Rita Khodosh,Teresa Fu,Ervin H. Epstein,Montserrat Molgó,Philip A. Beachy,Jean Y. Tang +10 more
TL;DR: Itraconazole reduced BCC tumor size, tumor proliferation, and Hedgehog pathway activity in this exploratory study, demonstrating the possibility of repurposing FDA approved drugs for the treatment of cancers driven by the Hedgehog signaling pathway.
Journal ArticleDOI
Cellular and molecular mechanisms of Hedgehog signalling
Yunxiao Zhang,Philip A. Beachy +1 more
Posted ContentDOI
Hedgehog pathway activation through conformational blockade of the Patched sterol conduit
Yunxiao Zhang,Wan Jin Lu,David P. Bulkley,Jiahao Liang,Arthur Ralko,Kelsey J. Roberts,Li A,Wonhwa Cho,Yifan Cheng,Yifan Cheng,Aashish Manglik,Philip A. Beachy +11 more
TL;DR: The conformation-selective nanobody approach provides a new route to the development of transporter-related pharmacologic agents and may be generally applicable to the study of other transporters.