P
Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
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Patent
Wnt Pathway Antagonists
TL;DR: Aromatic compounds for treating various diseases and pathologies are disclosed in this paper, where methods use of such compounds are also provided, and the present invention makes available methods and compositions for inhibiting aberrant growth states in cells having Wnt receptors.
Journal ArticleDOI
Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
Haruhiko Akiyama,H. Scott Stadler,James F. Martin,Takahiro Ishii,Philip A. Beachy,Takashi Nakamura,Benoit de Crombrugghe +6 more
TL;DR: Evidence is provided that Sox9 induces ectopic chondrogenesis in mesenchymal cells and strongly suggest that its expression may be regulated by Hox genes during limb bud development.
Journal ArticleDOI
Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex.
TL;DR: Since the unp protein is localized to the nucleus of tracheal precursor cells as they migrate and extend, unp protein appears to play a regulatory role in neural branching of the tracheae, and the segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of unp expression.
Journal ArticleDOI
Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells
Chen Zhao,Shang Cai,Kunyoo Shin,Kunyoo Shin,Agnes Lim,Tomer Kalisky,Wan Jin Lu,Michael F. Clarke,Philip A. Beachy +8 more
TL;DR: The findings suggest that Gli2 specifies a stromal niche signaling program that critically regulates MaSC activity, which is particularly intriguing in organs such as the breast, where the niche provides local signals for tissue homeostasis but also must be entrained by circulating hormones that induce the dramatic changes of puberty.
Journal ArticleDOI
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
Chin Chiang,Philip A. Beachy +1 more
TL;DR: The isolation and characterization of a novel gene, tlr (for Toll-like receptor), which encodes a protein containing multiple LRRs in its presumed extracellular domain, a single transmembrane segment and homology to the cytoplasmic domain of the interleukin 1 receptor in its presumption intracellular domain are reported.