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Philip A. Beachy
Researcher at Stanford University
Publications - 195
Citations - 44174
Philip A. Beachy is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog signaling pathway & Hedgehog. The author has an hindex of 88, co-authored 190 publications receiving 41427 citations. Previous affiliations of Philip A. Beachy include University of Wisconsin-Madison & Johns Hopkins University.
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Dispatched conformational dynamics couples transmembrane Na+ flux to release of lipid-modified Hedgehog signal
TL;DR: The Na+-coordinating residues resolved in the DISP1 structures are wholly or partly conserved in some of the other metazoan RND family members, such as PTCH1 and NPC1, suggesting the utilization of Na+ flux to power their conformationally-driven activities.
Proceedings ArticleDOI
FK-506 (Tacrolimus), Identified In A High Throughput Screen To Increase Bmprii Signaling, Prevents Pulmonary Arterial Hypertension (PAH) In Mice With Endothelial Bmprii Deletion
Edda Spiekerkoetter,Leila Haghighat,Roxanna Haghighat,Hirofumi Sawada,Toshie Saito,Lingli Wang,Vinicio A. de Jesus Perez,Peter ten Dijke,Nesrine El-Bizri,David E. Solow-Cordero,Philip A. Beachy,Marlene Rabinovitch +11 more
Journal ArticleDOI
Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis.
Shaheen S. Sikandar,Gunsagar S. Gulati,Jane Antony,I. Fetter,Angera H. Kuo,W. H. D. Ho,Veronica Haro-Acosta,Soumyashree Das,Chloé B. Steen,Thiago Almeida Pereira,Dalong Qian,Philip A. Beachy,F. Dirbas,Kristy Red-Horse,Terence H. Rabbitts,Jean Paul Thiery,Aaron M. Newman,Michael F. Clarke +17 more
TL;DR: In this paper , the authors identified a minority population of immature THY1+/VEGFA+ tumor epithelial cells in human breast tumor biopsies that display angiogenic features and are marked by the expression of the oncogene, LMO2.
Journal ArticleDOI
Mp57-04 human bladder transcriptome at single cell resolution in disease-free and tumor-bearing tissue
Bernhard Kiss,Aaron M. Kershner,Lolita Penland,Edward C. Diaz,Joseph C. Liao,Philip A. Beachy +5 more
TL;DR: The population of bladder epithelial cells in normal looking tissue from cancer-bearing bladder is substantially different from tissue from disease free bladder, containing cells with molecular characteristics typical of tumors.
Posted ContentDOI
LMO2 is critical for early metastatic events in breast cancer
Shaheen S. Sikandar,Jane Antony,Gunsagar S. Gulati,Angera H. Kuo,Ho Whd,Soumyashree Das,Chloé B. Steen,Pereira Ta,Dalong Qian,Philip A. Beachy,Frederick M. Dirbas,Kristy Red-Horse,Rabbitts Th,Jean Paul Thiery,Aaron M. Newman,Michael F. Clarke +15 more
TL;DR: In this article, a minority population of immature THY1+/VEGFA+ tumor epithelial cells in human breast tumor biopsies were identified that display angiogenic features and are marked by the expression of the oncogene, LMO2.