Philip N. Lewis

TL;DR: The first three-dimensional electron microscopic reconstructions of the cornea are presented, and it is proposed that the characteristic pseudohexagonal fibril arrangement in cornea is controlled by the balance of a repulsive force arising from osmotic pressure and an attractive force due to the thermal motion of the proteoglycans.

TL;DR: It is shown that cell-free implants are potentially safe, efficacious options for treating high-risk patients and a biomaterials-enabled pro-regeneration strategy to restore corneal integrity in an open-label observational study of six patients.

TL;DR: The corneal stroma of the Chst5-null mouse exhibited widespread structural alterations in collagen fibrillar architecture, including decreased interfibrillsar spacing and a more spatially disorganized collagen array, and the enzymatic sulfation of KS GAG chains is identified as a key requirement for PG biosynthesis and collagen matrix organization.

TL;DR: The macromolecular components of the corneal stroma are reviewed, the way they are organized into a stacked lamellar array, and how this organization guarantees Corneal transparency is reviewed.

TL;DR: It is argued that elastic sheets will play an important role in the biomechanical deformation and recovery of the peripheral cornea and may have practical implications for understanding the structural basis behind a number of corneal surgeries.