Christel Rousseaux

TL;DR: It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.

TL;DR: The authors found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut.

TL;DR: PPAR-γ is identified as a target of 5-ASA underlying antiinflammatory effects in the colon, and its activities are associated with the recruitment of coactivators and the activation of a peroxisome-proliferator response element–driven gene.

TL;DR: The peroxisome proliferator activated receptor γ (PPARγ) is a nuclear receptor highly expressed in the colon and playing a key role in bacterial induced inflammation Regulation of colon inflammation by this receptor has been well demonstrated in many experimental models of colitis but also in patients with ulcerative colitis, characterised by impaired expression of PPARγ confined to their colon epithelial cells as discussed by the authors.

TL;DR: Mesenteric fat is an important source of CRP in Crohn's disease and production by mesenteric adipocytes may be triggered by local inflammation and bacterial translocation to mesEnteric fat, providing a mechanism whereby mesenteri fat hyperplasia may contribute to inflammatory response in CD.