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Philippe Lesnik
Researcher at University of Paris
Publications - 75
Citations - 5766
Philippe Lesnik is an academic researcher from University of Paris. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 30, co-authored 72 publications receiving 4858 citations. Previous affiliations of Philippe Lesnik include Micalis Institute & National Institutes of Health.
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Journal ArticleDOI
Lipoprotein(a) as a cardiovascular risk factor: current status
Børge G. Nordestgaard,M. John Chapman,Kausik K. Ray,Jan Borén,Felicita Andreotti,Gerald F. Watts,Henry N. Ginsberg,Pierre Amarenco,Alberico L. Catapano,Olivier S. Descamps,Edward A. Fisher,Petri T. Kovanen,Jan Albert Kuivenhoven,Philippe Lesnik,Luis Masana,Zeljko Reiner,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen +18 more
TL;DR: The robust and specific association between elevated Lp(a) levels and increased cardiovascular disease (CVD)/coronary heart disease (CHD) risk, together with recent genetic findings, indicates that elevated LP(a), like elevated LDL-cholesterol, is causally related to premature CVD/CHD.
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Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
M. John Chapman,Henry N. Ginsberg,Pierre Amarenco,Felicita Andreotti,Jan Borén,Alberico L. Catapano,Olivier S. Descamps,Edward A. Fisher,Petri T. Kovanen,Jan Albert Kuivenhoven,Philippe Lesnik,Luis Masana,Børge G. Nordestgaard,Kausik K. Ray,Zeljko Reiner,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen,Gerald F. Watts +18 more
TL;DR: Recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal, and that therapeutic targeting of elevated triglycerides, a marker of TRL and their remnants, and/or low HDL-C may provide further benefit.
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Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor
TL;DR: The interaction of individual LDL subspecies with the LDL receptor on cultured human U-937 monocyte-like cells was compared by determining receptor binding affinities at 4 degrees C and scatchard analysis of specific binding curves demonstrated a single class of binding site for each subspecies.
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Macrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage
Emmanuel L. Gautier,Thierry Huby,Joseph L. Witztum,Betty Ouzilleau,Elizabeth R. Miller,Flora Saint-Charles,Pierre Aucouturier,M. John Chapman,Philippe Lesnik +8 more
TL;DR: It is suggested that macrophage apoptosis is atheroprotective in fatty streak lesions, but in contrast, defective clearance of apoptotic debris in advanced lesions favors arterial wall inflammation and enhanced recruitment of monocytes, leading to enhanced atherogenesis.
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Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-1 Reduces Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice
Mustapha Rouis,C. Adamy,Nicolas Duverger,Philippe Lesnik,Philippe Horellou,Martine Moreau,Florence Emmanuel,Jean-Michel Caillaud,P. M. Laplaud,C. Dachet,M. J. Chapman +10 more
TL;DR: Investigation of adenovirus-mediated elevation in the circulating levels of human tissue inhibitor of MMP (TIMP-1) in atherosclerosis-susceptible apolipoprotein E-deficient mice revealed increases in collagen, elastin, and smooth muscle alpha-actin content in mice treated with rAd.