P
Philippe Lesnik
Researcher at University of Paris
Publications - 75
Citations - 5766
Philippe Lesnik is an academic researcher from University of Paris. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 30, co-authored 72 publications receiving 4858 citations. Previous affiliations of Philippe Lesnik include Micalis Institute & National Institutes of Health.
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Journal ArticleDOI
Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response
Eric Frisdal,Philippe Lesnik,Maryline Olivier,Paul Robillard,M. John Chapman,Thierry Huby,Maryse Guerin,Wilfried Le Goff +7 more
TL;DR: The results indicate that IL-6 favors the elimination of excess cholesterol in human macrophages and phagocytes by stimulation of ABCA1-mediated cellular free cholesterol efflux and attenuates the macrophage proinflammatory phenotype.
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Anticoagulant activity of tissue factor pathway inhibitor in human plasma is preferentially associated with dense subspecies of LDL and HDL and with Lp(a).
TL;DR: The distribution and anticoagulant activity of TFPI among plasma lipop protein subspecies separated by isopycnic density gradient ultracentrifugation was examined; this procedure permitted the simultaneous fractionation of the major lipoprotein classes.
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Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity
Kavya Anjani,Kavya Anjani,Kavya Anjani,Marie Lhomme,Nataliya Sokolovska,Nataliya Sokolovska,Nataliya Sokolovska,Christine Poitou,Christine Poitou,Christine Poitou,Judith Aron-Wisnewsky,Judith Aron-Wisnewsky,Judith Aron-Wisnewsky,Jean-Luc Bouillot,Philippe Lesnik,Philippe Lesnik,Philippe Lesnik,Pierre Bedossa,Pierre Bedossa,Anatol Kontush,Anatol Kontush,Anatol Kontush,Karine Clément,Karine Clément,Karine Clément,Isabelle Dugail,Isabelle Dugail,Isabelle Dugail,Joan Tordjman,Joan Tordjman,Joan Tordjman +30 more
TL;DR: Circulatory (portal and systemic) phospholipid profiling and clinical data defines NASH signature in morbid obesity, and weak contribution of visceral adipose tissue to NASH-related portal lipid alterations is reported, suggesting possible contribution from other organs draining into hepatic portal system.
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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Amine Toubal,Amine Toubal,Amine Toubal,Badr Kiaf,Badr Kiaf,Badr Kiaf,Lucie Beaudoin,Lucie Beaudoin,Lucie Beaudoin,Lucie Cagninacci,Lucie Cagninacci,Lucie Cagninacci,Moez Rhimi,Blandine Fruchet,Jennifer Da Silva,Alexandra J. Corbett,Yannick Simoni,Yannick Simoni,Yannick Simoni,Olivier Lantz,Jamie Rossjohn,Jamie Rossjohn,James McCluskey,Philippe Lesnik,Emmanuelle Maguin,Agnès Lehuen,Agnès Lehuen,Agnès Lehuen +27 more
TL;DR: Mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.
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Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.
TL;DR: The results suggest that loading human monocyte-derived macrophages with free cholesterol induces upregulation of TF expression, thereby contributing to thrombus formation at sites of plaque rupture.