Piergiuseppe Colombo

TL;DR: Blocking CCL2 nitration in tumors promoted CD8+ influx and reduced tumor growth and prolonged survival in mice when combined with adoptive cell therapy.

TL;DR: PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.

TL;DR: Using a genetic approach complemented by adoptive transfer, it is found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis and type 1 immunity against murine sarcomas and selected human tumors.

TL;DR: It is shown that Dssignificantly depends on the number of vessels and their pattern of distribution, which demonstrates that the quantitative evaluation of the 2-D geometrical complexity of tumor vascular systems can be useful not only to measure its complex architecture, but also to model its development and growth.

TL;DR: In vivo results show that OTA-induced liver injury involves a reduction in the ability to counterbalance oxidative stress, maybe leading to altered gap junction intercellular communication and loss of cell adhesion and polarity, which suggests that mild oxidative damage might be a key factor in triggering the promotion of liver tumors after exposure to OTA.