Pierre-Yves Jeandel

TL;DR: Obesity appears to be a major environmental factor contributing to the onset and progression of autoimmune diseases.

TL;DR: In this paper, a family with a dominantly inherited autoinflammatory disease, distinct from FMF, characterized by childhood-onset recurrent episodes of neutrophilic dermatosis, fever, elevated acute-phase reactants, arthralgia, and myalgia/myositis, was caused by a mutation in MEFV, the gene encoding pyrin (S242R).

TL;DR: This disease provides evidence that a guard-like mechanism of pyrin regulation, originally identified for Nod-like receptors in plant innate immunity, also exists in humans, which guards against autoinflammation in humans.

TL;DR: This review will dissect the microbial actors thought to be involved in the Hygiene Hypothesis as well as their immunomodulatory mechanisms as emphasized by experimental studies, with a particular attention on parasites.

TL;DR: About 50% of patients with C1-INH-HAE type I or II have previously had their conditions misdiagnosed, most commonly as allergic angioedema or appendicitis, which results in marked delays in receiving the correct diagnosis.