H
Hilary Longhurst
Researcher at Barts Health NHS Trust
Publications - 114
Citations - 6356
Hilary Longhurst is an academic researcher from Barts Health NHS Trust. The author has contributed to research in topics: Hereditary angioedema & Angioedema. The author has an hindex of 32, co-authored 95 publications receiving 5316 citations. Previous affiliations of Hilary Longhurst include National Health Service & Queen Mary University of London.
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Journal ArticleDOI
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond.
Angelo Agostoni,Emel Aygören-Pürsün,Karen Binkley,Alvaro Blanch,Konrad Bork,Laurence Bouillet,Christoph Bucher,Anthony J. Castaldo,Marco Cicardi,Alvin E. Davis,Caterina De Carolis,Christian Drouet,Christiane Duponchel,Henriette Farkas,Kalman Fay,Béla Fekete,Bettina Fischer,Luigi Fontana,George Füst,Roberto Giacomelli,Albrecht Gröner,C. Erik Hack,George Harmat,John Jakenfelds,Mathias Juers,Lajos Kalmar,Pál Novák Kaposi,István Karádi,Arianna Kitzinger,Tímea Kollár,Wolfhart Kreuz,Peter L. Lakatos,Hilary Longhurst,Margarita López-Trascasa,Inmaculada Martinez-Saguer,Nicole Monnier,István Nagy,Éva Németh,Erik Waage Nielsen,Jan H. Nuijens,Caroline O'Grady,Emanuela Pappalardo,Vincenzo Penna,Carlo Perricone,Roberto Perricone,Ursula Rauch,Olga Roche,E. Rusicke,Peter J. Späth,George Szendei,Edit Takács,Attila Tordai,Lennart Truedsson,Lilian Varga,Beáta Visy,Kayla Williams,Andrea Zanichelli,Lorenza C. Zingale +57 more
TL;DR: This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy, and includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; and suggested prophylaxis and acute attack treatment.
Journal ArticleDOI
2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
Tom Bowen,Marco Cicardi,Henriette Farkas,Konrad Bork,Hilary Longhurst,Bruce L. Zuraw,Emel Aygoeren‐Pürsün,Timothy J. Craig,Karen Binkley,Jacques Hébert,Bruce Ritchie,Laurence Bouillet,Stephen Betschel,Della Cogar,John M. Dean,Ramachand Devaraj,Azza Hamed,Palinder Kamra,Paul K. Keith,Gina Lacuesta,Eric Leith,Harriet Lyons,Sean R. Mace,Barbara Mako,Doris Neurath,Man-Chiu Poon,Georges-Etienne Rivard,R. Robert Schellenberg,Dereth Rowan,Anne Rowe,Donald Stark,Smeeksha Sur,Ellie Tsai,Richard Warrington,Susan Waserman,Rohan Ameratunga,Jonathan A. Bernstein,Janne Björkander,Kristylea Brosz,John Brosz,Anette Bygum,Teresa Caballero,Michael M. Frank,George Füst,George Harmat,Amin Kanani,Wolfhart Kreuz,Marcel Levi,Henry Li,Inmaculada Martinez-Saguer,Dumitru Moldovan,István Nagy,Erik Waage Nielsen,Patrik Nordenfelt,Avner Reshef,E. Rusicke,Sarah Smith-Foltz,Peter J. Späth,Lilian Varga,Zhi Yu Xiang +59 more
TL;DR: Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches.
Journal ArticleDOI
Clinical picture and treatment of 2212 patients with common variable immunodeficiency
Benjamin Gathmann,Nizar Mahlaoui,Laurence Gérard,Eric Oksenhendler,Klaus Warnatz,I. Schulze,Gerhard Kindle,Taco W. Kuijpers,Rachel T. van Beem,David Sanchez-Migallon Guzman,Sarita Workman,Pere Soler-Palacín,Javier de Gracia,Torsten Witte,Reinhold E. Schmidt,Jiri Litzman,Eva Hlaváčková,Vojtech Thon,Michael Borte,Stephan Borte,Stephan Borte,Dinakantha S. Kumararatne,Conleth Feighery,Hilary Longhurst,Matthew Helbert,Anna Szaflarska,Anna Sediva,Bernd H. Belohradsky,Alison Jones,Ulrich Baumann,Isabelle Meyts,Necil Kutukculer,Per Wågström,Nermeen Galal,Joachim Roesler,Evangelia Farmaki,Natalia Zinovieva,Peter Ciznar,Efimia Papadopoulou-Alataki,Kirsten Bienemann,Sirje Velbri,Z. Panahloo,Bodo Grimbacher,Bodo Grimbacher +43 more
TL;DR: In this article, the authors analyzed the clinical presentation, association between clinical features, and differences and effects of immunoglobulin treatment in Europe for Common Variable Immunodeficiency (CVID) patients.
Journal ArticleDOI
Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group
Marco Cicardi,Konrad Bork,Teresa Caballero,Timothy J. Craig,Huamin Henry Li,Hilary Longhurst,Avner Reshef,Bruce L. Zuraw +7 more
TL;DR: Evidence‐based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group.
Journal ArticleDOI
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.
Tanya I. Coulter,Anita Chandra,Chris M. Bacon,Judith Babar,James Curtis,Nicholas Screaton,John R. Goodlad,George Farmer,Cathal Laurence Steele,Timothy Ronan Leahy,Rainer Doffinger,Helen Baxendale,Jolanta Bernatoniene,J. David M. Edgar,Hilary Longhurst,Stephan Ehl,Carsten Speckmann,Bodo Grimbacher,Anna Sediva,Tomas Milota,Saul N. Faust,Anthony P. Williams,Grant Hayman,Zeynep Yesim Kucuk,Rosie Hague,Paul French,Richard Brooker,Peter Forsyth,Richard Herriot,Caterina Cancrini,Paolo Palma,Paola Ariganello,Niall Conlon,Conleth Feighery,Patrick J. Gavin,Alison Jones,Kohsuke Imai,Mohammad A. A. Ibrahim,Gašper Markelj,Mario Abinun,Frédéric Rieux-Laucat,Sylvain Latour,Isabelle Pellier,Alain Fischer,Fabien Touzot,Jean-Laurent Casanova,Anne Durandy,Siobhan O. Burns,Sinisa Savic,Dinakantha S. Kumararatne,Despina Moshous,Sven Kracker,Bart Vanhaesebroeck,Klaus Okkenhaug,Capucine Picard,Sergey Nejentsev,Alison M. Condliffe,Andrew J. Cant +57 more
TL;DR: The severity of complications in some patients supports consideration of hematopoietic stem cell transplantation for severe childhood disease and clinical trials of selective PI3K&dgr; inhibitors offer new prospects for APDS treatment.