다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

A fast-Fourier-transform method of topography and interferometry is proposed. By computer processing of a noncontour type of fringe pattern, automatic discrimination is achieved between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour-generation techniques. The method has advantages over moire topography and conventional fringe-contour interferometry in both accuracy and sensitivity. Unlike fringe-scanning techniques, the method is easy to apply because it uses no moving components.

Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry

We review the recent developments in the area of optical fiber grating sensors, including quasi-distributed strain sensing using Bragg gratings, systems based on chirped gratings, intragrating sensing concepts, long period-based grating sensors, fiber grating laser-based systems, and interferometric sensor systems based on grating reflectors.

Fiber grating sensors

The PASCAL Visual Object Classes Challenge

Guiding, controlling and studying cellular functions are challenging themes in the biomedical field, as they are fundamental prerequisites for new therapeutic strategies from tissue regeneration to controlled drug delivery. In recent years, multidisciplinary studies in nanotechnology offer new tools to investigate important biophysical phenomena in response to the local physical characteristics of the extracellular environment, some examples are the mechanisms of cell adhesion, migration, communication and differentiation. Indeed for reproducing the features of the extracellular matrix in vitro, it is essential to develop active devices that evoke as much as possible the natural cellular environment. Our investigation is in the framework of studying and clarifying the biophysical mechanisms of the interaction between cells and the microenvironment in which they exist. We implement an optical tweezers setup to investigate cell material interaction and we use Digital Holography as non-invasive imaging technique in microscopy. We exploit Holographic Optical Tweezers arrangement in order to trap and manage functionalized micrometric latex beads to induce mechanical deformation in suspended cells. A lot of papers in literature examine the dynamics of the cytoskeleton when cells adhere on substrates and nowadays well established cell models are based on such research activities. Actually, the natural cell environment is made of a complex extracellular matrix and the single cell behavior is due to intricate interactions with the environment and are strongly correlated to the cell-cell interactions. Our investigation is devoted to understand the inner cell mechanism when it is mechanically stressed by point-like stimulus without the substrate influence.

Investigation on cytoskeleton dynamics for no-adherent cells subjected to point-like stimuli by digital holographic microscopy and holographic optical trapping

Nano- and pico-droplets have been extracted and dispensed from sessile drop or liquid film reservoirs through pyroelectric effect activated by a hot tip or an IR laser source on polar dielectric substrates.

Dispensing Nanolitre Droplets for Liquid Nanoprinting and Nanopatterning

This feature issue of Biomedical Optics Express presents a cross-section of interesting and emerging work of relevance to the use of biological cells or microorganisms in optics and photonics. The technologies demonstrated here aim to address challenges to meeting the optical imaging, sensing, manipulating and therapy needs in a natural or even endogenous manner. This collection of 15 papers includes the novel results on designs of optical systems or photonic devices, image-assisted diagnosis and treatment, and manipulation or sensing methods, with applications for both ex vivo and in vivo use. These works portray the opportunities for exploring the field crossing biology and photonics in which a natural element can be functionalized for biomedical applications.

Biological Cells as Natural Biophotonic Devices: Fundamental and Applications-introduction to the feature issue.

Through adaptive deformation of digital holograms it is possible to manage and control the depth of focus in 3D imaging. Objects lying at different distances can be set simultaneously infocus.

Adaptive deformation of digital holograms for full control of depth-of-focus in 3D imaging

We introduce a novel imaging modality, named Space-Time Scanning Interferometry (STSI), which synthesizes interferograms mapped in a hybrid space-time domain. A single linear sensor array is sufficient to build up synthetic interferograms with unlimited Field of View (FoV) along the scanning direction, reduced noise, and allowing quantitative phase retrieval. We applied the STSI method to in-flow on-chip microscopy of biological samples. Out-of-focus recordings are performed using a single line detector, in order to synthesize an unlimited FoV Space-Time Digital Hologram (STDH) yielding full-field, 3D information. Experimental proofs have been carried out to demonstrate the useful capability of STDH to overcome the trade-off existing between FoV and sample magnification, thus providing a high-throughput, label/free, quantitative, diagnostic tool to study biological elements onboard LoC platforms.

Pietro Ferraro

Papers

Investigation on cytoskeleton dynamics for no-adherent cells subjected to point-like stimuli by digital holographic microscopy and holographic optical trapping

Dispensing Nanolitre Droplets for Liquid Nanoprinting and Nanopatterning

Biological Cells as Natural Biophotonic Devices: Fundamental and Applications-introduction to the feature issue.

Adaptive deformation of digital holograms for full control of depth-of-focus in 3D imaging

Custom field-of-view quantitative label-free microscopy by optofluidic space-time digital holography