P
Po Zhao
Researcher at Children's National Medical Center
Publications - 28
Citations - 4084
Po Zhao is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: MyoD & Myogenesis. The author has an hindex of 19, co-authored 27 publications receiving 3901 citations. Previous affiliations of Po Zhao include George Washington University.
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Journal ArticleDOI
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
Marcella Fulco,Yana Cen,Po Zhao,Eric P. Hoffman,Michael W. McBurney,Anthony A. Sauve,Vittorio Sartorelli +6 more
TL;DR: These experiments reveal that AMPK, Nampt, and SIRT1 are the molecular components of a functional signaling pathway that allows skeletal muscle cells to sense and react to nutrient availability.
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Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
Marcella Fulco,R. Louis Schiltz,Simona Iezzi,M. Todd King,Po Zhao,Yoshihiro Kashiwaya,Eric P. Hoffman,Richard L. Veech,Vittorio Sartorelli +8 more
TL;DR: Results indicate that Sir2 regulates muscle gene expression and differentiation by possibly functioning as a redox sensor in response to exercise, food intake, and starvation, Sir2 may sense modifications of the redox state and promptly modulate gene expression.
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Expression Profiling in the Muscular Dystrophies Identification of Novel Aspects of Molecular Pathophysiology
TL;DR: It is hypothesize that the abnormal Ca2+ influx in dystrophin- and α-sarcoglycan–deficient myofibers leads to altered developmental programming of developing and regenerating my ofibers, and that primary genetic defects can be identified by a reduction in the corresponding RNA.
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Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb–MyoD pathways in muscle regeneration
Marina Bakay,Zuyi Wang,Zuyi Wang,Gisela Melcon,Louis Schiltz,Jianhua Xuan,Po Zhao,Vittorio Sartorelli,Jinwook Seo,Jinwook Seo,Elena Pegoraro,Corrado Angelini,Ben Shneiderman,Diana M. Escolar,Yi-Wen Chen,Sara T. Winokur,Lauren M. Pachman,Chenguang Fan,Raul N. Mandler,Yoram Nevo,Erynn Gordon,Yitan Zhu,Yibin Dong,Yue Wang,Eric P. Hoffman +24 more
TL;DR: A transcriptional model for downstream consequences of LMNA and emerin mutations is developed and it is proposed that key interactions between the nuclear envelope and Rb and MyoD fail in EDMD at the point of myoblast exit from the cell cycle, leading to poorly coordinated phosphorylation and acetylation steps.
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The RNA Helicases p68/p72 and the Noncoding RNA SRA Are Coregulators of MyoD and Skeletal Muscle Differentiation
Giuseppina Caretti,R. Louis Schiltz,F. Jeffrey Dilworth,Monica Di Padova,Po Zhao,Vasily Ogryzko,Frances V. Fuller-Pace,Eric P. Hoffman,Stephen J. Tapscott,Vittorio Sartorelli +9 more
TL;DR: Reducing the levels of p68/p72 proteins impaired recruitment of the TATA binding protein TBP; RNA polymerase II; and the catalytic subunit of the ATPase SWI/SNF complex, Brg-1, and hindered chromatin remodeling.