Qianhui Yu

TL;DR: This work used homogeneous human bud tip organoid cultures and identified SMAD signaling as a key regulator of the bud tip-to-airway transition and shed light on human airway differentiation in vitro and provides a single-cell atlas of the developing human lung.

TL;DR: This work uses single-cell mRNA sequencing with in situ validation approaches to interrogate human intestinal development from 7-21 weeks post conception, assigning molecular identities and spatial locations to cells and factors that comprise the niche.

TL;DR: This work generates a single-cell transcriptome atlas from multiple developing endodermal organs of the respiratory and gastrointestinal tract and implements the atlas as a high-dimensional search space to benchmark human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) under multiple culture conditions.

TL;DR: Functional data from enteroid cultures showed that NRG1 improved cellular diversity, enhanced the stem cell gene signature, and increased enteroid forming efficiency, whereas EGF supported a secretory gene expression profile and stimulated rapid proliferation.

TL;DR: In this article , the up-to-date literatures on the functional properties of flavonoids, phenols, terpenoids and polysaccharides of hawthorn are discussed.