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Quentin Simon

Researcher at French Institute of Health and Medical Research

Publications -  38
Citations -  791

Quentin Simon is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Thin film & B cell. The author has an hindex of 13, co-authored 30 publications receiving 549 citations. Previous affiliations of Quentin Simon include University of Rennes & European University of Brittany.

Papers
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Journal ArticleDOI

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Andreia C. Lino, +30 more
- 17 Jul 2018 - 
TL;DR: A novel subset of natural regulatory plasma cells characterized by the expression of LAG‐3 that develops at steady state independently of microbiota, and respond to innate stimulation by producing immunosuppressive IL‐10 is identified.
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B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner.

A. Nouël, +6 more
- 01 May 2015 - 
TL;DR: The results show that activated B cells regulate T cell proliferation through producing transforming growth factor (TGF)-β and indoleamine 2,3-dioxygenase (IDO) and evidenced for the first time that CTLA-4 induces B-cells to produce IDO and to become effective induced regulatory B cells (iBregs).
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In-depth characterization of CD24(high)CD38(high) transitional human B cells reveals different regulatory profiles.

Quentin Simon, +5 more
- 01 May 2016 - 
TL;DR: Evidence is provided for the existence of different transitional B-cell subsets, each displaying unique phenotypic and regulatory functional profiles in patients with different autoimmune diseases.
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Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases.

Guillermo Barturen, +131 more
- 01 Jun 2021 - 
TL;DR: This study identified molecular clusters for reclassifying systemic autoimmune diseases independently of clinical diagnosis to identify molecular clusters defined by molecular pattern.
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Human regulatory B cells control the TFH cell response

Achouak Achour, +8 more
- 01 Jul 2017 - 
TL;DR: Novel observations demonstrate a role for the Breg cell in germinal center reactions and suggest that deficient activities might impair the TFH cell–dependent control of humoral immunity and might lead to the development of aberrant autoimmune responses.